The Manchester derby is always a high stakes affair, but this Saturday's must surely take on an extra edge.
Manchester City go to Old Trafford in danger of being cut adrift in the title race. The Citizens suffered a surprise defeat at Crystal Palace last week and are now five points behind leaders Chelsea, who simply don't look like faltering right now.
When, where and how to watch
When: Saturday, November 6, 12.30pm BST
Where: Old Trafford
How to watch: Sky Sports
Best bets for Manchester United vs Manchester City
Man City are not looking as dominant as they did last season, but they should have enough to see off Man Utd here and ramp up the pressure on Solskjaer another notch (if there are any notches left).
You have to fancy they will be the better prepared of the two sides and a comfortable away win would surprise no one.
However, Man Utd have enough quality to get on the scoresheet themselves. Cristiano Ronaldo may struggle for chances if Man City dominate midfield and possession, so back Bruno Fernandes instead.
Finally, it is a fixture that has produced eight red cards in the Premier League, so it's always worth checking out that market too.
If you don't fancy any of these selections, then watch our tipster Pete Farries' thoughts on the big match.
Last time out
Tottenham 0-3 Manchester United (October 30, 2021)
All the pre-match build-up before this one was of Ole Gunnar Solskjaer losing his job. As it turned out, a manager did get the axe, but it was Spurs boss Nuno Espirito Santo instead.
Man Utd's pride had clearly been hurt by the 5-0 home defeat to Liverpool a week before, and predictably they came out fighting at Tottenham Hotspur Stadium.
From the moment Cristiano Ronaldo brilliantly volleyed them ahead six minutes before half-time, they never looked like letting a big three points slip their grasp.
Premier League form (most recent first): WLLDL
Manchester City 0-2 Crystal Palace (October 30, 2021)
This was a result that absolutely no one saw coming and it highlighted Man City's failure to sign a striker during the summer.
It's fair to say that even when Wilfried Zaha fired Palace ahead in the sixth minute, no one really expected it to last. However, a red card for Aymeric Laporte on the stroke of half-time changed the game.
City still poured forward, but they were always going to be vulnerable to a counter-attack and when the hugely impressive Connor Gallagher wrapped it up two minutes from time no one could really deny the Eagles had earned it.
Premier League form (most recent first): LWWDW
Premier League head-to-head for Man Utd vs Man City
Man Utd wins: 24
Man City wins: 15
Man Utd goals: 71
Man City goals: 61
Red Devils far too nice
There can absolutely be no doubting that Man Utd have an obscene amount of quality in their squad. That hasn't always been the case in recent years.
Their problem has been that they are too nice a team to really assert themselves on games.
That definitely stems from the manager. Solskjaer was called the 'baby-faced assassin' as a player and he was as likeable and inoffensive a top player as you're likely to find.
Is that what Man Utd need, though? Surely they need a much more ruthless character, a pure winner who is willing to climb over whoever it takes to be successful.
That was a quality that defined Sir Alex Ferguson's Manchester United, but never since - and they are simply not going to win another Premier League title until they rediscover it.
Striker shortage starting to hurt City?
When Man City opted to allow Sergio Aguero to walk away at the end of last season, it definitely felt like the right time.
Harry Kane looked set to replace him and possibly even improve them, but they had not planned for Daniel Levy's infamous stubbornness.
Kane did not arrive, and that in itself was not a problem. The problem was that no one did.
That left Gabriel Jesus and Ferran Torres to carry the goalscoring burden. Both are fine players, neither are truly elite. Torres is also out injured now.
Manchester United vs Manchester City goalscorer bets
Cristiano Ronaldo is, of course, always a go-to man for Man Utd, and he proved it again by grabbing the vital opening goal at Spurs and the last-gasp equaliser at Atalanta in midweek.
However, consider Bruno Fernandes instead for this one. Bruno has not scored for Man Utd since the 4-1 win over Newcastle, and he has a feel of a player who is due. United may need something spectacular in what could be a tight game and he is their best bet for that.
Manchester City, meanwhile, have used Foden in a false nine position in their last two games and he is likely to continue that role at Old Trafford.
The youngster opened the scoring from that position in the Champions League win over Brugge this week, so expect him to go into this one with his tail up.