Gareth Southgate is expected to make a host of changes as he looks to rest key players ahead of Wednesday's crunch tie with Poland. With that in mind, the likes of Conor Coady, Jordan Henderson and Jude Bellingham are also expected to feature.
When, where and how to watch
When: Sunday, September 5, 17:00PM BST
Where: Wembley Stadium
How to watch: ITV
England took a major step towards World Cup qualification last Thursday following their 4-0 victory over Hungary in Budapest.
The result leaves the Three Lions top of the group - five points clear of Poland and the Hungarians.
Southgate's men shouldn't have any problems in continuing that run against a side they've comfortably dispatched on four previous occasions.
The current aggregate score stands at 16-0 and that is expected to increase substantially this Sunday.
With that in mind, one of the stand out tips is to back the over 5.5 goals bet at 11/10.
Last three matches
England 6-0 Andorra (World Cup Qualifier - June 10, 2009)
England enjoyed a comfortable night at Wembley last time they welcomed Andorra to the capital.
Wayne Rooney and Jermain Defoe scored twice while further efforts from Frank Lampard and Peter Crouch completed a comprehensive 6-0 win.
Andorra 0-2 England (World Cup Qualifier - September 6, 2008)
On what proved to be a bittersweet night, England picked up a 2-0 win over Andorra in their 2010 World Cup Qualifier.
Two goals from Joe Cole helped Fabio Capello's men to all three points. However, the mere two-goal margin did leave a lot to be desired.
Andorra 0-3 England (Euros Qualifier - March 28, 2007)
Capello wasn't the only manager who struggled to secure a comprehensive win away against Andorra.
Steve McClaren was the man in charge when the Three Lions picked up a 3-0 victory at the Estadio Olimpico de Montjuic.
After a scoreless first-half, England eventually found the back of the net as two goals from Steven Gerrard and one from David Nugent sealed the three points.
Last four head-to-heads
England wins: 4
Andorra wins: 0
England goals: 16
Andorra goals: 0
Southgate to make changes
Little has troubled England during this qualifying campaign. The Three Lions are yet to drop a point and they've only conceded one goal.
With that in mind, this upcoming game against Andorra is an opportunity for Southgate to give some of his fringe players a chance to shine.
The likes of Jude Bellingham (who continues to impress at Borussia Dortmund) and Jordan Henderson (who hasn't played full 90 minutes for England since 2019) could all start as Southgate looks to rotate his side.
With the likes of Bellingham, Henderson and even Conor Coady classed as fringe players, the strength in depth of this England side is clear for all to see.
The Three Lions are expected to win big at Wembley and considering the wealth of talent that Southgate still has to his disposal, our tip is to back the hosts in the -4.75 Asian Handicap.
Another player who could make a big impact is Patrick Bamford.
His consistent performances for Leeds United in the Premier League have caught the eye of Gareth Southgate who could hand the forward his England debut.
Should he feature, our tip is to back the Leeds man to score a header at 11/5.