The two clubs have very different ambitions this season, with Leicester targeting European football and Palace content in midtable.
However, both are in need of points after an uninspiring run of results, so we could be in for a feisty one.
When, where, and how to watch
When: Sunday, October 3, 2PM BST
Where: Selhurst Park
How to watch: Sky Sports
Crystal Palace vs Leicester best bets
Last three meetings
Leicester 2-1 Crystal Palace (Premier League - April 26, 2021)
The Foxes certainly proved their cunning in this one as they were forced to come from behind to earn all three points.
Wilfried Zaha handed Palace an early lead, and they successfully negotiated their way to half-time with it still in tact.
However, a resurgent Leicester emerged for the second half and were able to turn the game around, courtesy of goals from Timoty Castagne and Kelechi Iheanacho.
Crystal Palace 1-1 Leicester (Premier League - December 28, 2020)
It was a similar tale in this one too, with Crystal Palace waning late in the game and Leicester able to take full advantage.
Zaha was the man on the scoresheet for the Eagles again, with the former Manchester United man apparently possessing a taste for netting against the Foxes.
They were unable to convert that into three points though, as Harvey Barnes bagged the equaliser just seven minutes from time.
Leicester 3-0 Crystal Palace (Premier League - July 4, 2020)
Jamie Vardy was at the double in this one, although the scoreline suggests it was much more one-sided than it really was.
The first half was a tight one with neither side seemingly willing to take too many risks, but again it was a different Leicester that came out after half time.
Iheanacho scored the first just four minutes after the restart with Vardy adding some glass late on with his brace.
Crystal Palace vs Leicester Premier League head-to-head
Crystal Palace wins: 8
Leicester wins: 7
Crystal Palace goals: 25
Leicester goals: 20
Eagles' defining spell of the season?
Crystal Palace attempted to move away from the cold, yet effective, pragmatism of Roy Hodgson last summer and turned to Premier League legend Patrick Vieira instead.
Things haven't gone badly - this is not a Frank de Boer situation - but you also feel Palace are still waiting to really get going.
They have won just one of their six league matches so far this season, although three draws have kept them ticking over.
That said, things are still looking just a little precarious for now. They will be conscious of the fact they need to put a couple of wins together to avoid the danger of getting dragged into the relegation scrap that will emerge over the next month.
Pick up plenty of points, and it should set them up for a solid mid-table campaign. Fail, and they'll be smack bang in the middle of a relegation scrap that won't give them up easily.
Leicester struggling for form - and defenders
Leicester started this season brilliantly, and they looked like they were about to establish themselves very early as a firm contender for Champions League spots.
It hasn't worked out that way, and Brendan Rodgers is currently overseeing his first real slump as Foxes manager.
Much of that is down to injuries - specifically in defence. Jonny Evans has been among those absent and his influence cannot be understated.
How quickly they can get the former Manchester United man back in the heart of their defence may go a long way to deciding how quickly they overcome this slump.
Wilfried Zaha is very much still Crystal Palace's main man and he has a taste for Foxes.
Zaha has scored the opening goal in each of his last two games against Leicester, and he seems a good bet to do that again, particularly if he has taken over penalty-taking duties.
For Leicester, the goalscoring burden as ever appears to have fallen on Jamie Vardy.
He has a good record against Palace too, and he can be backed to bag a brace at around 9/1.