Chelsea are London's top dogs right now but who are the capital's second best team?
Victory for the Gunners (26pts) in this midweek derby would see them leapfrog the Hammers (28pts) but an away win would stretch West Ham five clear of Mikel Arteta's hosts.
When: Wednesday, December 15, 20.00 GMT
Where: The Emirates
Best bets for Arsenal vs West Ham
Arsenal were rock bottom after starting the season with three straight losses but have worked their way up the table nicely.
And yet barely a phone-in goes by without panellists or Gunners fans debating whether Arteta is the right man for the job.
Those doubts have risen up again after a trio of recent away defeats, at Anfield, Old Trafford and Goodison.
There were excuses for the first two but Arsenal were rotten at Everton and defeat was deserved.
The good news, though, is their home form. Arsenal have won four straight at the Emirates and no top-flight team has bagged more points (19) in front of their own fans than the Gunners this term.
The latest count is six wins and a draw from their last seven after a 3-0 home success over Southampton at the weekend.
While Arsenal have won 73% of their points at home, West Ham's points accrual has been a 50:50 split.
Both their home and away records show won four, drawn two, lost two and they've got a slightly better goal difference on their travels.
Last three meetings
West Ham 3-3 Arsenal (March 21, 2021)
West Ham looked to be cruising to three points after racing into a 3-0 lead with just 32 minutes on the clock but they were undone by a second-half Arsenal revival.
Jesse Lingard's superb volley put the Hammers in front and Jarrod Bowen and Tomas Soucek extended their advantage before Soucek deflected an Alexander Lacazette effort past his own goalkeeper seven minutes before the break.
Arsenal completed the fightback via another own goal, this one from Craig Dawson on 61, and a Lacazette header eight minutes from time.
The result kept West Ham in fifth and Arsenal eighth with nine games to play.
Arsenal 2-1 West Ham (September 19, 2021)
Arsenal made it two wins out of two to start the new season as Eddie Nketiah struck the winner five minutes from time.
Lacazette headed home on 25 but Michail Antonio ensured parity at the break by forcing home Ryan Fredericks' cross.
Antonio later hit the bar but Arsenal condemned West Ham to a second straight loss by tapping home with the clock ticking down.
Arsenal 1-0 West Ham (March 7, 2020)
West Ham suffered a sixth straight away loss to leave them level on points alongside third-bottom Bournemouth with just nine games of the season left.
They had the better chances and should have taken at least a point but the contest was settled when Lacazette fired home from close range in the 78th minute.
That gave Arsenal a third straight home win and moved them to ninth in the table, five behind Chelsea in fourth.
Past 10 meetings
Arsenal wins: 7
West Ham wins: 1
Arsenal goals: 20
West Ham goals: 8
Arsenal can cash in on home advantage
The Emirates is only a short hop away for West Ham fans but the tube journey home is never much fun.
Why? West Ham have suffered defeat in 10 of their last 11 Premier League trips to Arsenal.
Even at home it's been grim, with the Hammers managing just two wins in the last 26 meetings with their London rivals.
If the relevance of those historical head-to-heads can be argued away, Arsenal's current home form certainly can't be dismissed.
They've taken 19 points out of the last 21 available at the Emirates and that's unsurpassed even by the top three.
It's reflected in the odds although some may be happy to see Arsenal at an odds-against price: they're 21/20 to rack up three more points.
That's perhaps a little tight given how strong West Ham can be so I'll go for the higher odds by backing Arsenal to win and both teams to score.
That inflates the price to 14/5 and it seems fair to give the Hammers a goal.
True, they couldn't break down Burnley at the weekend but home goalkeeper Nick Pope was man-of-the-match as the visitors came out ahead on all the attacking stats.
Only the top three have netted more away goals than West Ham so they're an attacking threat even though on this occasion, I expect the Gunners to outscore them.
Goalscorer bets for Arsenal vs West Ham
All roads seem to lead to Alexander Lacazette in this one.
The Frenchman has scored in his last three games against West Ham (see above) and has five goals against them in all.
Check through the records and against no team has he scored more!
In addition, he scored the opener in the 3-0 win over Southampton on Saturday so his confidence is up.
Back Lacazette to score anytime at 11/8.
The goals have dried up for Michail Antonio and his failure to score at Turf Moor stretched his drought in West Ham colours to eight matches.
A more imaginative selection for a West Ham scorer is Declan Rice.
The midfielder is much more box-to-box these days and gets plenty of shots off. Overall, he's netted four times for club and country this term.
That's already more than he managed last season while it's also worth noting that he got the winner in a 1-0 home win over Arsenal in 2019.
Rice is 11/2 to wheel away in celebration.