Over the years, this has been an exhilarating fixture with plenty of goals and drama to spare.
With both teams enjoying recent league wins, we could be heading for yet another thrilling battle between Spurs and the Hammers.
When, where and how to watch
When: Sunday, October 24, 2PM BST
Where: London stadium
How to watch: Sky Sports
Best bets for West Ham vs Tottenham
Many saw West Ham's sixth-placed finish last season as a bit of a one-off. However, the Hammers are beginning to prove those doubters wrong after kicking off this new campaign on a similarly strong footing.
David Moyes and his men enter this fixture in seventh place after winning four of their eight league games this season.
West Ham have performed strongly despite the added strain of Europa League soccer. In fact, the Hammers seem to have embraced their Thursday night obligations having won all three of their group games in comfortable fashion.
Spurs, on the other hand, are very unpredictable this season. Nuno Espirito Santo's men were on a three-match winning run before facing an embarrassing 1-0 loss away to Vitesse last Thursday.
Tottenham did rest a number of players but that's no excuse for only producing one shot on target against an average Eredivisie outfit.
Santo's men have an opportunity to turn their fortunes around this Sunday as they look for their third win over the Hammers in five games.
There's little to separate both these clubs at the minute and a draw seems to be the logical way to go in the betting.
Last three meetings
West Ham 2-1 Tottenham (Premier League - February 2, 2021)
Tottenham's last visit to the London stadium ended in disappointing fashion as they were beaten 2-1 by the Hammers.
Michail Antonio and Jesse Lingard gave the hosts a two-goal cushion before a Lucas goal halved the gap in the second-half.
Nevertheless, Spurs were unable to complete a comeback.
Tottenham 3-3 West Ham (Premier League - October 10, 2020)
Speaking of comebacks, try this one for size.
Tottenham took a three-goal lead inside 15 minutes during their last home outing against the Hammers.
However, with eight minutes remaining, West Ham pulled off one of the most memorable comebacks in this fixture's history.
Fabian Balbuena, Davinson Sanchez (own goal) and Manuel Lanzini somehow cut the deficit to secure a famous point for Moyes' men.
Tottenham 2-0 West Ham (Premier League - June 23, 2020)
There were no comebacks when the two teams clashed in the summer of 2020.
Tottenham - under Jose Mourinho's leadership at the time - sealed all three points following an own goal from Tomas Soucek and a late Kane effort.
Last 10 head-to-heads
West Ham wins: 3
West Ham goals: 15
Tottenham goals: 19
Historical advantage for the visitors
Over the years, this has been a fixture which has favoured the away team.
Six of the last ten meetings have been won by the visiting side while only twice has a home team managed to reign supreme.
One of those rare occasions took place last season when the Hammers kept hold of all three points at the London stadium.
While many fans still dream about the old Boleyn ground, it's fair to say that the club's new home is finally beginning to feel like... home.
The adjusting process has taken many years but it seems that finally the Hammers are able to turn the former Olympic stadium into a fortress.
Out of their last 18 games at home, West Ham have picked up 11 victories. What's more, only twice have they been kept scoreless during that run.
With that in mind, our second selection is to back the hosts to open the scoring.
Tottenham attract bookings
The number of bookings in games featuring Tottenham seems to have increased over the past couple of weeks.
In fact, there have been 23 bookings across their last five matches.
London derbies have a propensity to get tasty and with Tottenham attracting a lot of cards, it may be a good idea to explore the bookings market.
As things stand, the over 4.5 cards bet is well priced at around the 23/20 mark.