While a lot of the upcoming games appear to be dead rubbers, there are three which could actually be quite competitive.
The clash between Ipswich and Colchester is definitely one of them as both teams look to seal a place in the play-off stage of the competition.
Elsewhere, there's a battle at the top of the group between Charlton Athletic and League Two side Leyton Orient.
The third game is also a battle between the two best sides in their group as Sheffield Wednesday host Harrogate in a much-anticipated Yorkshire derby.
Without further to do, let's get straight into our EFL Treble - one which has been enhanced from 11/2 to a massive 13/2.
Ipswich Town vs Colchester
Ipswich kicked off the season with an eight-match winless run. Since that faltering start, few teams have been able to stop the Tractor Boys from winning.
Paul Cook's side have won five from their last eight games in all competitions and they are expected to maintain that run against Colchester.
Unlike Ipswich, the League Two outfit are out-of-form having won just four of their last 11 games.
The one major concern with regards to Hayden Mullins' side is their stuttering goal scoring record. In 15 league games, the U's have only managed to bag an uninspiring haul of 12 efforts.
With that in mind, League One's Ipswich should bank the win and a place in the next stage of the EFL Trophy.
Leyton Orient vs Charlton Athletic
The season may still be in its early stages but Leyton Orient are already building a strong reputation for their toughness and hard work.
Out of 19 games in all competitions, this is a club which has only suffered three defeats - one of those coming against Championship outfit QPR after a penalty shootout.
Another big challenge awaits the O's as they prepare for the visit of Charlton.
After a slow start to the season, the Addicks are beginning to string together an impressive run of results.
However, with Johnnie Jackson's men facing a potentially tricky league encounter at the weekend against Burton, it's likely that a lot of key players could be rested this Tuesday night.
With that in mind, this could be the perfect opportunity for Orient to take a big scalp on the road to the EFL Trophy play-offs.
Sheffield Wednesday vs Harrogate
Both Sheffield Wednesday and Harrogate have enjoyed a perfect record in the EFL Trophy this season.
However, this Tuesday night somebody's O will have to go when the pair go head-to-head at Hillsborough.
Looking at recent results, it's the hosts who should retain their perfect record.
The Owls are unbeaten in eight games and they will be determined to extend that run against a fellow Yorkshire outfit.
Harrogate have hit a bit of a slump, managing just one victory from their last five games.
Simon Weaver's men have lost three of their last four in the league and it's likely that the EFL Trophy will be at the bottom of his priorities list considering his side already have a place in the play-offs.
Wednesday are the ones to back on Tuesday night.