With so many games on offer, you may be inclined to have a punt. However, instead of dipping into the outright market, here at Planet Sport we may have something a little more adventurous for you.
After a look at all the fixtures, stats and team news, we've come up with five player bets, ranging from anytime goalscorer to bookings.
Here are the five selections…
Declan Rice to score anytime (West Ham vs Genk)
When you think about West Ham this season, you think goals. When you think goals, you immediately think Michail Antonio.
And why shouldn't you? The striker has scored five goals in seven Premier League appearances and is absolutely flying.
However, with Antonio priced at 4/6 in the anytime goalscorer market, he doesn't exactly scream value. Instead, you might want to think about Declan Rice.
The England international is yet to get of the mark in the league, but when it comes to European soccer, he boasts a perfect record.
The 22-year-old midfielder has bagged two goals in two games and we fancy him to add to that total.
Realistically speaking, the Hammers should do the business against a Genk side who have lost four of their last five.
With that in mind, surely Rice will get one or two opportunities to improve on his stellar Europa League goalscoring record.
Karl Toko Ekambi to score anytime (Sparta Prague vs Lyon)
Another man who can't seem to stop scoring in the Europa League is Lyon's Karl Toko Ekambi.
The Cameroon international is on an impressive scoring run, bagging six goals in nine games across all competitions.
Three of those goals arrived in the Europa League with the 29-year-old helping Lyon to comprehensive wins over Rangers and Brondby.
Lyon come into their game against Sparta Prague having never lost to the Czech Republic outfit in four previous meetings.
What's more, last weekend's 2-0 win over Monaco will give Peter Bosz's side a lot of encouragement.
Ekambi got on the scoresheet in that game and we're backing him to do it against on Thursday at around the 21/10 mark.
Mario Gotze to get an assist (PSV vs Monaco)
Mario Gotze (you all still remember him, right?) was in fine goalscoring form at the start of the season. The German bagged four efforts in four games as PSV made early progress in the Champions League qualifiers.
Since then, a lot has changed. Gotze's goals have dried up while PSV failed to secure Champions League soccer and had to make do with Thursday night European action.
Despite not finding the back of the net as often, Gotze remains influential in other areas - mainly assists.
In his eight most recent games, the World Cup winner has set up five goals - three of those coming in the Europa League.
PSV's next opponents are Monaco, meaning Gotze will need to have another solid outing if PSV are to maintain their current winning run.
The former German international is currently priced at 7/2 to deliver another assist. With odds like that, we can get behind him every night of the week.
Victor Osimhen to score the last goal (Napoli vs Legia)
If you haven't heard of Victor Osimhen, don't worry. In a year or two, Premier League's big guns will be after him like there's no tomorrow.
The Nigeria international is in the midst of a stupendous run of form having scored nine goals in nine competitive games for club and country.
Osimhen is among the Europa League's best goal-getters with three efforts in two games to his name. Interestingly, the 22-year-old was the last goalscorer in both games.
With that in mind, our fourth selection is to back the Napoli forward to close out the show against Legia Warsaw with the final goal of the game.
With the bet available at 3/1, it makes for a great selection.
Artur Jedrzejczyk to be booked (Napoli vs Legia)
Staying with Napoli against Legia Warsaw, there's a second bet that may have gone under the radar.
With the Italian outfit expect to dominate proceedings, the cards market may be the one to back from Legia's perspective.
The Polish champions are currently top of their Europa League group, but with the team struggling on the domestic front, surely it's just a matter of time before they begin to trip up in Europe.
Legia's defender, Artur Jedrzejczyk, makes frequent appearances in the referee's book. In fact, the 33-year-old already picked up eight yellow cards this season across all competitions.
Despite those numbers, the player is well priced at 29/20 to get in trouble again. That's certainly not an offer we can pass up.