When: Sunday 21 March, 19:30 GMT
How to watch: Sky Sports
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Is a crisis emerging at Spurs?
'They have failed at all the basic things'. Those were the words of a dejected Jose Mourinho after his side chaotically crashed out of the Europa League round of 16, following a 3-0 defeat away to Dinamo Zagreb.
Sadly for the Portuguese manager, the calamity in Croatia only began to scrape the surface of the problems emerging at the North London club, who currently sit eighth in the Premier League table, four points clear of Villa in ninth.
Despite winning three of their last five Premier League games, a terrible week for Tottenham saw them throw away a 1-0 lead to lose the North London derby 2-1 to Arsenal, and disastrously lose their comfortable aggregate lead against Zagreb in the 3-0 collapse.
Amid reports emerging of Mourinho's future at the Tottenham Hotspur Stadium and civil unrest between coaching staff and players alike behind the scenes, it is pivotal that the three-time Premier League winner steadies the ship, and fast.
With a long-awaited Carabao Cup final clash awaiting them next month in champions-to-be, Manchester City - qualifying for another Europa League place will barely suffice should they go another season trophyless.
Spurs are currently one place behind Everton in the last European spot and six points off the top four - should they reignite the form that saw them top the Premier League table earlier this season, a strong finish to proceedings hasn't evaded them just yet.
Last three Premier League meetings
Aston Villa 2-3 Tottenham (February 16, 2020)
Despite a valiant Villa side comeback, Heung-min Son scored the decisive goal for Tottenham in stoppage time to win the game 3-2 for Mourinho's side, who picked up an important three points on the road.
In an eventful opening half-hour for the Belgian centre-back, Toby Alderweireld gifted Dean Smith's side the lead when he put the ball in his own goal, but later redeemed himself when he scored at the other end to level proceedings.
Spurs were awarded a penalty through a controversial VAR call that left Villa fans, players and staff alike baffled. Son subsequently converted to give Spurs the lead on the stroke of half-time.
It appeared as if Bjorn Engels' 53rd minute equaliser had been enough to salvage a point for the Villans, but Son struck again - this time at the end of the second-half - to sway the tie in Tottenham's favour once and for all.
Tottenham 3-1 Aston Villa (August 10, 2019)
A late Harry Kane brace secured a home victory for Tottenham who came from behind against Villa to secure a third consecutive Premier League victory against them on the opening day of the 2019/20 season.
Scottish midfielder John McGinn gave newly-promoted Villa the lead against the run of play after just nine minutes, superbly controlling a Tyrone Mings ball to slot past Hugo Lloris.
Despite controlling large periods of the first-half, Tottenham were unable to break down Dean Smith's side for all of 70 minutes until Tanguy Ndombele scored a sensational long-range debut goal to draw the two sides level.
Continuing the late momentum, Spurs talisman Harry Kane scored twice in the space of four minutes to put the game beyond Villa's reach and get Spurs off to a winning start to the season.
Aston Villa 0-2 Tottenham (March 13, 2016)
Goals from Andros Townsend and Roberto Soldado wrapped up a convincing away victory for Spurs at Villa Park.
In a game marred by controversy, referee David Bryan was struck by a flare from a celebrating Spurs fan in the aftermath of Townsend's opener.
Villa manager Paul Lambert encouraged his side to push on and find some goal after bringing Belgian striker Christian Benteke on, but it wasn't to be for the Villans, who fell to yet another defeat.
Head-to-head in the Premier League
Aston Villa won: 14
Tottenham won: 21
Aston Villa scored: 54
Tottenham scored: 71
Will we see European football at Villa Park next season?
Having already surpassed their points tally of last season by six points with 11 games to go, all but sealing their safety and heading for a top-half finish, the sky's the limit for Dean Smith's Villa side in the forthcoming Premier League fixtures.
Villa currently sit in ninth position, bettering Arsenal on goal difference and four points behind Tottenham, with a game in hand on both North London clubs.
Their sensational start to the season accompanied with a number of players such as Douglas Luiz, Jack Grealish and Ollie Watkins maintaining periods of great form throughout the season have sparked conversation amongst Villa fans and neutrals alike on just how strongly they can finish this campaign.
A slight hindering factor for Dean Smith's side this season has been large spells of erratic form, resulting in very few periods of consecutive wins or unbeaten runs, if that particular issue can be steadied, they could well be an even greater force to be reckoned with next season.
Should they secure a much-needed victory in the Midlands this weekend, they could well be in with a chance of catching Everton in seventh, and bring those long-awaited European nights back to the bright lights of Villa Park.
Score Prediction: Aston Villa 2-2 Tottenham Hotspur
A large contributing factor in determining the outcome of this game will be which Tottenham side turn up in the Midlands tomorrow.
Although a win for Mourinho's men will be vital in getting their season back on track, low confidence levels and rising tensions behind the scenes may leave them largely vulnerable to Villa's fearless, free-flowing attacking football.
With this in mind, Tottenham should have enough fire-power in Gareth Bale and usual suspects in Harry Kane and Heung-min Son to hold their own in this one.
A 2-2 draw seems about fair in this one.
After failing to keep his side in Europe in the midweek slump at Zagreb, Harry Kane will be determined to fire his club back to winning ways.
Having recently been called up to the England squad for the first time, Ollie Watkins will be determined to prove Gareth Southgate right, especially with Patrick Bamford scoring another goal for Leeds against Fulham on Friday.