When: Sunday, May 9, 14:05 GMT
How to watch: Sky Sports Main Event
The Red Devils have little chance of actually challenging for the title however, if they can close the gap, it could at least underline the progress that Ole Gunnar Solskjaer's men have made.
In recent times, United have turned into a goal-happy team - mostly to the credit of Fernandes and Cavani. Those two names will also play a key role against Aston Villa.
Dean Smith's side are currently down in 11th spot and need to win if they stand any chance of making the top seven. Inconsistent results have seen them drop down the standings but they do possess enough tools to threaten the Red Devils.
Last Three Matches
Man United 2-1 Aston Villa (Premier League - January 1, 2021)
Goals from Anthony Martial and Bruno Fernandes helped Man United to a 2-1 win over the Villains in their meeting earlier this season.
The Frenchman opened the scoring in the 40th minute as the Red Devils went into the interval with a slender lead.
Bertrand Traore equalised in the 58th minute for Villa however, their celebrations didn't last long.
Just three minute later, Fernandes converted a Man United penalty as Solskjaer's men took all three points.
Aston Villa 0-3 Man United (Premier League - July 9, 2020)
United made light work of their opponents when they met last year at Villa Park.
First half goals from Bruno Fernandes and Mason Greenwood gave the visitors a comfortable two-goal lead going into half-time.
Paul Pogba added a third in the second period to make sure of all three points.
Man United 2-2 Aston Villa (Premier League - December 1, 2019)
In a much closer affair, Aston Villa held out for a draw when they visited Old Trafford back in 2019.
Jack Grealish opened the scoring in the 11th minute however, United equalised when Tom Heaton deflected the ball into his own net.
Victor Lindelof put United ahead in the 64th minute however, their advantage didn't last long either.
Tyrone Mings equalised two minutes later as Aston Villa held on for a point in Manchester.
Last ten head-to-heads
Aston Villa wins: 0
Man United wins: 8
Aston Villa goals: 6
Man United goals: 23
Can Villa end winless run?
Aston Villa haven't beaten Man United since 2009 - that is a run of 17 straight games.
Changing that is a major task however, not an impossible one by any stretch of the imagination.
Dean Smith's men have been rather inconsistent over the last few months however, his side enjoyed a strong performance in their 2-1 win over Everton last weekend.
Potential return of Jack Grealish would certainly boost their hopes even further.
Edinson Cavani is the man to watch in this game. If the striker features, he is bound to extend his goal scoring tally.
The Uruguayan forward propelled United to the Europa League final and it's no surprise that United are keen to sign him up for another season.
Ollie Watkins is another man to watch. The Villa frontman has bagged 13 Premier League goals this season and scored the opener in two of his last four starts.