Goals from James Maddison and Harvey Barnes were enough to secure the three points for the Foxes, putting them five points clear of fifth placed Chelsea. They stand in a strong spot for Champions League football next season.
Jamie Vardy has faced the North London side twelve times in a Leicester shirt, and has an impressive 11 goals against them in that time.
Here we look at his top five matches against Arsenal:
Leicester City 3-0 Arsenal - King Power Stadium, 28th April 2019
The English bagsman got his name on the scoresheet twice late on as Leicester crushed the Gunner's chances of a top four spot.
Youri Tielemans got Leicester's opener just before the hour mark as he headed in a James Maddison cross past goalkeeper Bernd Leno.
With minutes remaining, a cheeky chip from Vardy bounced off the crossbar and on the second attempt he headed the ball into the open Arsenal net.
Adding salt to the wound, Vardy was later gifted a tap-in following some excellent play by teammate Ricardo Pereira, giving the striker his second of the game and his third brace against Arsenal.
Leicester City 2-0 Arsenal - King Power Stadium, 9th November 2019
Jamie Vardy contributed to both goals as his side once again outclassed Arsenal in front of home fans.
Deadlock was broken with just 22 minutes of the game remaining as Vardy converted an excellent team move by curling the ball into the bottom left corner.
The Foxes then doubled their lead through James Maddison as he drilled the ball past a frozen Leno, after Vardy excellently laid his teammate off just outside the box.
The win moved Leicester to second in the league after twelve games and left Vardy as the league's top goalscorer with 11 goals already that season.
Arsenal 4-3 Leicester City - Emirates Stadium, 11th August 2017
Another brace for Vardy against Arsenal wasn't enough this time as his team was on the losing side of a seven-goal thriller.
With the score 1-1 after just five minutes, Vardy gifted his side the lead on the half hour mark as he smashed the ball from close-range past Petr Cech.
Arsenal equalised through Danny Welbeck just before the break, but ten minutes into the second half Vardy had his side back in front as he steered the ball with his head into the bottom left corner.
Two late Arsenal goals from Aaron Ramsey and Olivier Giroud earned Arsenal all three points. Nevertheless, Vardy once again proved prolific against the Gunners defence and was Leicester's strongest performer on the day.
Leicester City 2-5 Arsenal - King Power Stadium, 26th September 2015
Once again, a Vardy brace was not enough for his side to take anything from this game, but his performance is worth a mention nonetheless.
The Englishman opened the scoring just thirteen minutes into the game in typical fashion, as he controlled a long ball over the top and blasted the ball past Cech before he had chance to move.
However, a late consolation goal from Vardy meant he continued his strong start to the campaign, and was once again the star player for Ranieri's men.
His performance earned him an exceptional 9.3 rating on WhoScored.com, as he landed the most shots (6) and most tackles (4) for his side.
Arsenal 0-1 Leicester City - Emirates Stadium, 25th October 2020
Despite only featuring for 30 minutes, Vardy once again left his mark on the game as his goal was the only thing to split the two sides earlier this season.
Having missed the previous two games through a calf injury, Vardy was reintroduced on the hour mark in London, and wasted no time in terrorising the Arsenal backline once again.
With ten minutes remaining, Vardy coolly found the net with his head following a smart pass from fellow substitute Cengiz Under, and this proved to be the only goal of the match.
Vardy may have only had eleven touches of the ball, yet he came close once again late on as his effort was well-stopped by an in-form Leno.
The goal ended a 262-minute goal drought for the Foxes and earned them their fourth win of the season. This week, they will be hoping to make it four league wins on the bounce in their reverse fixture at home.
Tip for the fixture
Skybet are offering odds of 23/10 on a Leicester City win and Vardy goal in the match-up this weekend.