When: Sunday, April 18, 13:30 GMT
How to watch: Sky Sports Main Event
Mikel Arteta's men have enjoyed two solid victories last week but considering the level of opposition they beat, it's too early to say whether the Gunners are truly firing on all cylinders.
Arsenal are still some way off the top six - seven points to be exact - and they simply can't afford to drop points if they're serious about challenging.
For Fulham, the situation is becoming desperate. After four straight defeats, time really is running out for Scott Parker's men.
The Lilywhites are seven points from safety with only six games remaining. They'll need to pull off a famous win at the Emirates if they are to give themselves a fighting chance of survival.
Last Three Matches
Fulham 0-3 Arsenal (Premier League - September 12, 2020)
This game marked the start of the 2020/21 Premier League campaign but for Fulham, it was certainly a forgettable afternoon.
The Gunners cruised to a 3-0 victory thanks to goals from Alexandre Lacazette, Gabriel and Pierre Emerick Aubameyang.
Fulham ended the day with a mere two shots on target and a big round zero on the scoreboard.
Arsenal 4-1 Fulham (Premier League - January 1, 2019)
The script followed a similar narrative when the two clubs met on the first day of 2019.
The Gunners dominated from the get go and took a 2-0 lead courtesy of Granit Xhaka and Lacazette.
Aboubakar Kamara pulled one back for the Lilywhites on the 70th minute mark however, Arsenal were never troubled again.
Instead, they sealed all three points with further goals from Aaron Ramsey and Aubameyang.
Fulham 1-5 Arsenal (Premier League - October 7, 2018)
Even back in 2018, Fulham fell to a heavy defeat against the Gunners.
Lacazette and Aubameyang ran riot as Arsenal scored five goals at Craven Cottage.
The game was relatively close in the opening half as Lacazette's opener was cancelled out by Andre Schurrle.
However, four more goals for Arsenal clinched all three points for the visitors. Lacazette, Ramsey and Aubameyang scored the goals in the second-half.
Last ten head-to-head games
Arsenal wins: 6
Fulham wins: 1
Arsenal goals: 25
Fulham goals: 11
Six games left to avoid the drop
Sheffield United marked their Saturday evening with a 1-0 loss to Wolves. The result meant that Paul Heckingbottom's Blades became the first team to be officially relegated.
If Fulham are to avoid a similar outcome, they must begin picking up points - starting with this weekend's game against Arsenal.
After their trip to the Emirates, Fulham face games with Chelsea, Burnley, Southampton, Man United and Newcastle. Not exactly the easiest of run-ins.
Arsenal's final chance for European places
The Gunners are through to the Europa League semi-finals where they will take on Villarreal - a club led by former Arsenal boss, Unai Emery.
Winning that competition would earn the Gunners a spot in next season's Champions League. However, winning the Europa League is a lot easier said then done.
With that in mind, Arsenal could do with a back-up plan - finishing in the Premier League's top six.
Arteta's men are currently ninth and they trail sixth-placed Liverpool by seven points. However, the Gunners have recently began showing signs of improvement and they could mount a late challenge for that potential Europa League spot.
There is only one man that you need to consider in this market… Alexandre Lacazette.
The Frenchman is currently priced at 7/2 to score first but the better market is to back him to score last at that same price.
Lacazette scored last in Arsenal's win over Slavia Prague, in their win over Sheffield United, in their draw with West Ham and also in their North London derby win over Tottenham.