When: Sunday, May 23, 16:00 GMT
How to watch: Sky Sports
Bragging rights in North London at stake
Mikel Arteta has got the right tune out of his players in the Premier League in May, winning four from four.
What's more is that Arsenal now have the chance of bragging rights over their neighbours Tottenham Hotspur, who now sit just one point above The Gunners.
Victory this weekend and anything less than a win for Spurs would consign them to being the second-placed North London team once again.
Arsenal still have plenty to play for and will be aiming to be victorious for the fifth league game in a row, to end the season on a high.
Arsenal's last four Premier League results
1-3 - Crystal Palace (A)
0-1 - Chelsea (A)
3-1 - West Brom (H)
0-2 - Newcastle (A)
Last three Premier League meetings
Brighton 0-1 Arsenal (December 29, 2020)
Alexandre Lacazette struck a winner a mere 21 seconds after coming on as a substitute to help relieve pressure on manager Mikel Arteta.
Attackers Pierre-Emerick Aubameyang and Gabriel Martinelli went close for the London club, before Lacazette entered the pitch and produced the instant impact.
Brighton, as has been the story of their season, played well in possession but lacked any verve going forward and were eventually made to pay the price.
Brighton 2-1 Arsenal (June 20, 2020)
Very little action occurred in this meeting of the two teams until the 68th minute when Nicolas Pepe opened the scoring courtesy of a curling effort that left the goalkeeper with no chance.
No-nonsense defender Lewis Dunk then pounced to equalised after a well-worked corner to set up an interesting end to the match.
Neal Maupay, who arguably should have seen red earlier in the game, then scored the winner running onto an Aaron Connolly flick and finishing at the near-post five minutes into injury time.
Arsenal 1-2 Brighton (December 5, 2019)
Brighton secured their first ever victory at Arsenal on the ninth time of asking in this one, and in impressive fashion too.
In what was Freddie Ljungberg's first game as interim manager, this was seemingly one of the lowest points for Arsenal in years.
Arsenal, who had failed to keep a clean sheet in 11 matches, once again conceded when Adam Webster poked home to give Brighton a lead.
Alexandre Lacazette clawed the home team back into the game with a flicked header that looped over Mat Ryan in The Seagulls' goal.
However, another header, this time from Brighton striker Neal Maupay in the 80th minute would end Arsenal hopes and leave them 10 points adrift of the Champions League positions.
Premier League head-to-head
Arsenal wins: 2
Brighton wins: 3
Arsenal scored: 8
Brighton scored: 8
Seagulls still flying
Brighton's fixture with Arsenal this weekend will struggle to live up to their impressive comeback against champions Manchester City in midweek.
An early goal, an early sending off, two majestic solo goals, and two late goals from defenders ended with Brighton securing a crazy 3-2 win over Man City in front of 8,000 fans at the AMEX Stadium.
In what was their first league win over Man City since 1989, Brighton showed that they intend to finish as high as they can this season and victory over Arsenal would be another excellent scalp.
The attitude shown by the South Coast team was perhaps even more impressive than the result, especially after going 2-0 down straight after half time.
Many teams would have lay down and accepted defeat, but the belief on display proved the never-say-die attitude Graham Potter's men possess.
Scoreline prediction: Arsenal 2-1 Brighton
Both teams are in form and in recent seasons this fixture has thrown up close results, so we are going with a narrow home win as the most likely outcome.
Potter's men showed great character in their comeback but that is likely to have taken a lot out of his players.
A point would be a good result for the away team but considering they will be missing key players such as Neal Maupay and Lewis Dunk, a victory is a tough task for Brighton.
Arsenal have won their last four games and that cannot be overlooked.
Nicolas Pepe scored twice in Arsenal's previous game with two very different types of goals to show that he does have the ability to be a regular goalscorer.
Given the confidence he will take from his midweek performance, he may well back it up with another goal.
Pepe is available at 23/4 to score first with Unibet and 39/20 anytime.
Alexandre Lacazette has scored two in the last three meetings of these sides and boasts an impressive percentage of goals scored at home.
The French striker is fresh after not playing in midweek and is evens to score anytime with Paddy Power.