When: Monday, June 14, 22:00 BST
How to watch: BBC Sport
Just a few weeks before the start of the tournament, Argentina and Colombia were gearing up to host South America's biggest soccer event.
However, CONMEBOL's spectacular decision to strip the two nations of their hosting rights sent shockwaves and led to weeks of controversies.
Away from all the politics, there is also growing pressure on the national team after failing to win a major honour since 1993.
Since then, Argentina have lost one World Cup final, four Copa America finals and even two FIFA Confederations Cup finals.
Can Lionel Messi finally lead his men to a major international trophy? The next two tournaments - Copa America and the 2022 World Cup - will arguably be his last to try and cement his national team reputation.
Last Three Matches
Argentina 1-1 Chile (World Cup Qualifier - June 4, 2021)
The two teams recently met in a 2022 World Cup qualifier.
On that occasion, the two sides shared a point after Lionel Messi's opener was cancelled out by an Alexis Sanchez equaliser.
The result leaves Argentina in second place. Chile, meanwhile, are well off the pace in seventh.
Chile 0-0 Argentina (Friendly - September 6, 2019)
There was little to shout about when Chile and Argentina clashed in a friendly back in 2019.
A capacity crowd in Los Angeles went home rather disappointed following a goalless draw.
Argentina 2-1 Chile (Copa America - July 6, 2019)
The last meeting between the two sides in the Copa America came in a third-place play-off back in 2019.
Sergio Aguero opened the scoring after 12 minutes to put Argentina in-front. Just moments later, Paulo Dybala doubled that lead.
A few minutes before the interval, both Gary Medel and Lionel Messi were sent-off for unsportsmanlike conduct.
Chile closed the gap in the second-half when Arturo Vidal converted a penalty. Nevertheless, Argentina held on to finish the tournament in third place.
Last ten head-to-heads
Argentina wins: 6
Chile wins: 2
Argentina goals: 14
Chile goals: 8
End of an era is coming
Angel Di Maria, Sergio Aguero and Lionel Messi are arguably the three best players in this Argentina squad. They're also 33-years-old.
With the glory years behind them, these three are well aware that the next two major tournaments could be their last opportunities to win major international silverware.
The pressure is on to deliver but with a talented young squad behind them, there's no reason why Lionel Scaloni's side can't succeed.
Chile's tough start
On one hand, Chile have been dealt a horrendous draw having to play Argentina first. On the other, Martin Lasarte's side will be happy to get the big boys out of the way early.
With only three wins from their last 13 games, there is a growing concern about Chile's form.
The national side is struggling as their 'golden generation' seems to have spectacularly collapsed.
Lionel Messi bagged a goal when the two teams last met. In fact, Messi has scored four of his 72 international goals against Chile.
At 20/21, the Barcelona man is well priced to get amongst the goals.