Hertha Berlin vs Bayern Munich - Friday 19:00 GMT
The weekend kicks off with an intriguing clash in Germany between league leaders Bayern Munich and strugglers Hertha Berlin.
The team from the capital may be enduring a turbulent time. However, with a new manager in the dugout and Sami Khedira ready to be unleashed, perhaps there is light at the end of the tunnel.
For Bayern this promises to be a busy Friday night. This game was pushed forward by 30 minutes in order to accommodate their flight to Qatar for the FIFA Club World Cup. Could this potentially mess with their focus?
Betting: Draw at 5/1 (PaddyPower)
Fiorentina vs Inter Milan - Friday 19:45 GMT
Inter are enormous favourites ahead of this game but that shouldn't come as a big surprise.
Antonio Conte's men are currently second in the table. They are Serie A's most prolific goalscorers with 49 to their name and they're coming into Friday's game having had shutouts in their last three league games.
Fiorentina, on the other hand, are mid table and have accumulated their lowest points total at this stage of a season since 2002 - the same year they were relegated.
Only one winner in this one.
Betting: Inter to win by two goals at 10/3 (PaddyPower)
Freiburg vs Borussia Dortmund - Saturday 14:30 GMT
When looking at previous meetings, you get a feeling that this should be a walkover for Borussia Dortmund.
BVB are currently on a 19-game unbeaten run against Freiburg and they have only lost three of the previous 41 Bundesliga encounters.
However, the reality of the current situation has to be taken into account. Dortmund have been underperforming for a number of weeks and Freiburg are capable of an upset - Christian Streich's men haven't lost at home since November.
Betting: Double chance Freiburg and draw at 6/5 (PaddyPower)
Huesca vs Real Madrid - Saturday 15:15 GMT
In spite of their crisis, Real are huge favourites to get the better of La Liga's basement team. Karim Benzema played his part in five goals in his last two appearances against Huesca and if he plays, expect that stat to improve.
Betting: Karim Benzema to score two or more goals at 7/2 (PaddyPower)
Juventus vs AS Roma - Saturday 17:00 GMT
In what is arguably one of the biggest games of the weekend, Juventus host AS Roma in a monumental top-four clash.
Roma have a poor record against Andrea Pirlo's men. In fact, they have lost more league games against Juventus than they have against any other club.
The trouble for Juve is that Cristiano Ronaldo's goals seemed to have dried up, and their other major offensive threat, Alvaro Morata, has never scored against Roma despite facing the club on five occasions.
This, I'm afraid, is too close to call.
Betting: Draw at 3/1 (PaddyPower)
Manchester United vs Everton - Saturday 20:00 GMT
Consistency is not a word that can be associated with Man United's home form. Over these last two weeks alone, they beat Liverpool in the FA Cup, lost to Sheffield United in the Premier League and then beat Southampton by NINE goals to nil.
One thing that is consistent is Everton's incredible away form. A win at Old Trafford will take them to five straight away wins - something they last did in 1970 when they won the First Division title.
Carlo Ancelotti has won at Old Trafford with two other clubs and a third could be on the cards here…
Betting: Everton to win at 5/1 (PaddyPower)
AC Milan vs Crotone - Sunday 14:00 GMT
Top meets bottom this Sunday in the Serie A as leaders AC Milan host bottom-of-the-table Crotone.
Giovanni Stroppa's men have won fewer points on their travels than any other team in Europe's top five leagues this season. AC Milan, on the other hand, are enjoying their best season since 2003/04.
This could get ugly.
Betting: AC Milan to win 4-0 at 11/1 (PaddyPower)
Liverpool vs Manchester City - Sunday 16:30 GMT
It may only be the start of February but the importance of this game cannot be underestimated.
Pep Guardiola's men look near invincible at this moment and the same cannot be said for Liverpool who come into this game after two straight home defeats.
Betting: Manchester City to win at 1/1 (PaddyPower)
Sheffield United vs Chelsea - Sunday 19:15 GMT
There will be plenty at stake at Bramall Lane this Sunday when Sheffield United host Chelsea.
This game could be a lot closer than most anticipate due to United's much-improved form. Despite this, don't expect a draw as none of the last 15 meetings between these clubs in South Yorkshire have ended in a tie.
Chelsea are desperate for the three points as they continue to chase down the top four. They may have too much firepower for the Blades on this occasion.
Betting: Chelsea to win by one goal at 23/10 (PaddyPower)
Real Betis vs Barcelona - Sunday 20:00 GMT
Nine wins from ten! Barcelona may not be back to their absolute best but Ronald Koeman has got them winning games again.
Real Betis are enjoying a brilliant season and they could prove to be tricky opposition. Nevertheless, Barca like playing away at Betis having avoided defeat there for 13 years. There won't be many surprised if that run continues.
Betting: Barcelona to win and both teams to score at 6/4 (PaddyPower)
Marseille vs PSG - Sunday 20:00 GMT
What a way to end the weekend! Le Classique is back and it features a PSG side undergoing a Mauricio Pochettino rebuild and a Marseille side in total chaos.
Last time these two teams met in Ligue 1, there was utter carnage! The referee sent five players off and awarded a total of 14 yellow cards. On that occasion, it was Marseille who picked up a 1-0 win.
Back then Marseille were seen as potential title contenders. Now, things are much different. Manager Andre Villas-Boas has been suspended after criticizing the club over a signing which he did not want. Before that, fans of the club stormed to the training ground and forced the game with Rennes to be called off.
PSG are the favourites and they should get the job done. However, don't say I didn't warn you if things suddenly get a little spicy.
Betting: PSG to win 2-1 at 18/1 (PaddyPower)