*All betting tips courtesy of Sky Bet and at the time of writing.
Slavia Prague vs Arsenal
Arsenal have it all to do ahead of their visit to the Sinobo Stadium in Prague, as their hosts left north London with a late away goal courtesy of Tomas Holes, finishing 1-1.
The Gunners thought they had grasped victory from the hands of the Czech side after Nicolas Pepe left it late to break the deadlock himself, scoring four minutes from time.
Arsenal's route to where they find themselves was characterised by walking away from Group B with a 100% record, while sneaking past Benfica and Olympiakos in the previous knockout rounds by a goal on aggregate respectively.
Only three of the 11 Europa League games involving Mikel Arteta's side this season have finished under 2.5 goals, and with a 1-1 score draw not enough to secure progression in 90 minutes for either team, it looks to be set up for a goal fest in the Czech capital this evening.
To qualify: Arsenal (2/5)
Betting tip: Over 2.5 goals (1/1)
Villarreal vs Dinamo Zagreb
Gerard Moreno's penalty proves to be the difference between Unai Emery's and Damir Krznar's sides at the halfway point of the tie, as the Yellow Submarine took a vital away goal back to the Estadio de la Ceramica.
Zagreb had a goal ruled out after an offside in Mislav Orcic's goal before Moreno netted, but Villarreal will feel confident that they can meet either of Slavia Prague or Arsenal in the tournament's penultimate round.
The Spanish outfit have had an extraordinary unbeaten run to this point, conceding just six times, while Dinamo Zagreb finished top of Group K but have had a relatively more dramatic route to the quarter-finals.
Having beaten Krasnodar by three goals to two away from home, they triumphed over the Russians at the Stadion Maksimir before overcoming a two-goal deficit over the heavy favourites Tottenham Hotspur in the last 16, eventually winning 3-2 on aggregate.
Zagreb averaging 1.76 goals a game in Europe this season combined with Villarreal's aforementioned excellent defensive effort points towards routine progression for the Spaniards, but the taste for a comeback for the Purgeri will still remain and make for an interesting second leg.
To qualify: Villarreal (1/16)
Both teams to score: Yes (11/8)
Manchester United vs Granada
Manchester United ran out comfortable victors against tournament newbies in Granada, with Marcus Rashford and Bruno Fernandes doing the damage for the Red Devils in a 2-0 win.
The young Mancunian's class was on display for all to see with a deft touch and finish before the Portuguese talisman rounded off proceedings from the spot late on, with the only downside being Harry Maguire, Scott McTominay and Luke Shaw now ruled out of the second leg at Old Trafford after picking up booking suspensions.
Victories over Real Sociedad and AC Milan was preceded Ole Gunnar Solskjaer's side dropping down into Europe's second tier competition after finishing third in a group of PSG, RB Leipzig and Istanbul Basaksehir in the UEFA Champions League.
In comparison, the small regional side from Andalucia have perhaps overperformed in their maiden continental campaign, making the quarter-finals from the second qualifying round and overcoming giants such as Napoli in the process.
Chasing a two-goal deficit away from home will likely be too much for Diego Martinez's team, but United's likely tendency to rest some key players alongside their suspensions may allow for Granada to find the net, just as they have in all but one of their away Europa League matches this year.
To qualify: Manchester United (1/100)
Full time result and under/over 3.5 goals: Manchester Utd and Over 3.5 Goals in match (11/4)
Roma vs Ajax
Lorenzo Pelligrini and Roger Ibanez's strikes capitalised on Dusan Tadic's penalty miss and cancelled out Davy Klaasen's opener to enable somewhat of a 'smash-and-grab' victory in Amsterdam.
Ajax were much the better side with more of the ball (63%) and over double that of the Giallorossi's attempts (Ajax registered 15 attempts with nine on target to Roma's seven attempts and four on target).
Roma have only lost once so far this season in Europe and continued their five game winning streak last week, with other noteworthy wins in their campaign coming against the likes of Braga and Shakhtar Donetsk.
As the other remaining side to have dropped down from the Champions League, Atalanta advanced from Group D with a four-point cushion from the Dutch, with the latter since having to overcome Lille and Young Boys in their return to the competition they won in 1992 (then known as the UEFA Cup).
The visitors will arrive knowing they were much the better side last time out and will now have to make up for it on the scoresheet, albeit without record signing Sebastian Haller who will watch on from the sidelines after being left out of their Europa League squad list after an administrative error.
To qualify: Ajax (7/4)
Full time result and both teams to score: Ajax and Yes (9/4)