Tottenham FA Cup preparations set to be hardest hit by extra international window
Spurs will have three players away on World Cup qualifying duty next week, as will Aston Villa, Liverpool and Manchester City.
Manchester United, who will have Fred and Edinson Cavani in South America that week, have landed the dubious pleasure of the Friday night game.
That will make it hard for the likes of Michail Antonio, Raul Jimenez and Christian Pulisic to be back in England much before Friday morning. Antonio's West Ham have the lunchtime kick-off on the Saturday.
In terms of pure numbers, Tottenham, Aston Villa, Liverpool and Manchester City be hardest hit, although Villa are already out of the FA Cup. All four clubs will have three players away on World Cup duty. In Liverpool's case, they only add to the absences created by the ongoing Africa Cup of Nations, although at least Spurs do not have anyone at that tournament.
Let's take a look in more detail at which players will be involved in these forthcoming World Cup qualifiers.
Manchester City
Chelsea
Liverpool
Arsenal
Gabriel (Brazil)
West Ham
Michail Antonio (Jamaica)
Tottenham
Emerson (Brazil), Giovani Lo Celso (Argentina), Davinson Sanchez (Colombia)
Not picked: Heung-min Son (South Korea), Cristian Romero (Argentina), Lucas Moura (Brazil)
Manchester United
Wolves
Raul Jimenez (Mexico)
Not picked: Hwang Hee-chan (South Korea), Hayao Kawabe (Japan), Yerson Mosquera (Colombia)
Brighton
Alexis Mac Allister (Argentina)
Leicester
Southampton
Crystal Palace
Brentford
Aston Villa
Philippe Coutinho (Brazil), Emiliano Martinez, Emiliano Buendia (both Argentina)
Not picked: Douglas Luiz (Brazil), Leon Bailey (Jamaica)
Everton
Yerry Mina (Colombia), Salomon Rondon (Venezuela)
Not picked: Richarlison, Allan (both Brazil)
Leeds
Watford
Burnley
Newcastle
Norwich
Not picked: Josh Sargent (USA)