Serie A betting preview: Injuries set to catch up with makeshift Milan

Spezia can inflict more away woes on under-strength visitors, while Mourinho is sure to target Immobile in the Rome derby.

It promises to be a spicy few days in Italy's top flight with big games for Spezia and the Special One.

Andy Schooler picks out his best tips from the weekend's most high-profile fixtures.

Spezia vs AC Milan (Saturday, 2pm BST)

Ante Rebic AC Milan Sep21

Milan are having to make good use of their squad at the moment with injuries having piled up.

Defender and captain Simon Kjaer is a significant loss, while Ante Rebic looks set to continue as a makeshift centre-forward given the continued absence of Olivier Giroud and Zlatan Ibrahimovic.

Milan did return to winning ways in midweek with a 2-0 home victory over lowly Venezia but the high-fliers have found things trickier on their travels.

Since edging past Sampdoria 1-0 on the opening day, Milan have lost in the Champions League at Liverpool and drawn away to Juventus.

Clearly Spezia aren't at the same level as the latter two sides but they did give Juve a decent game in the week, losing 3-2 in the end and, having scored seven times - only Verona in the bottom half have more - they do look capable of troubling that weakened Milan defence.

Essentially, a price of 40/85 about an away win here makes little appeal and getting with the hosts via the double-chance market looks to have potential at 17/10.

Inter Milan vs Atalanta (Saturday, 5pm BST)

Edin Dzeko Inter Milan Sep21

Inter's 100 per cent start to the season should be tested by an Atalanta side who sit fifth after five rounds of Serie A.

The hosts haven't missed Romelu Lukaku. They already lead the league in goalscoring terms having bagged 14 in five matches with the experienced Edin Dzeko proving a shrewd signing. Lautaro Martinez continues to contribute too.

However, Atalanta have been tight at the back of late, conceding only four goals, and they've often made things hard for Inter in the past.

Seven of the last eight meetings have featured under 2.5 goals but thanks to Inter's goal-laden start - they've seen over 3.5 goals in all five games - you can get 6/5 about the unders here.

With just six goals conceded in 10 combined games, it's not that hard to envisage defences being on top and Inter having to really grind things out if they want another three points.

This may be the game where they miss Lukaku's spark and ability to snaffle a half-chance.

Lazio v Roma (Sunday, 5pm BST)

Jose Mourinho Roma Sep21

The Rome derby is Italy's big game of the weekend.

It will be Jose Mourinho's first in charge of Roma, nominally the visitors on this occasion, and it will be fascinating to see how he approaches this tactically after what has been a good start to the campaign for his new club.

The loss to suspension of Lorenzo Pellegrini is certainly a big blow - he's been firing off shots for fun this season, scoring three times - and so there will be more reliance on Tammy Abraham, who, like his manager, has hit the ground running in Serie A.

Lazio also depend a lot on their centre-forward, Ciro Immobile, who has continued his superb Serie A record by scoring six times already.

However, no one else has managed more than one and Mourinho will doubtless be working on a plan to stifle the Euro 2020 winner.

Ciro Immobile Lazio Torino Sep21

Immobile is evens to score at any time here but alternative market value could lie in Sergej Milinkovic-Savic, who is out at 15/4.

He has managed 11 shots, six of which have been on target. Admittedly he's only scored one goal (plus another for Serbia during the recent international window) but the midfielder has bagged eight and seven respectively in the last two Serie A campaigns.

That highlights his goal potential and he looks an interesting price this weekend.

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