Interestingly, the only team to claim all three points away at Southampton this season are Wolves who won 1-0 in the early weeks of the campaign.
This Tuesday night, it's Brentford's turn to try their luck away on the south coast. The Bees will head into this fixture on the back of successive victories - the first time that's happened since September.
In recent years, Brentford have enjoyed their trips to St Mary's and are currently on a four-match unbeaten run at the ground - their last visit ended in a 2-0 win in the Carabao Cup.
When, where and how to watch
When: Tuesday, January 11, 19:45 GMT
Where: St Mary's Stadium
How to watch: Not televised in the UK
Last head-to-head meeting
Southampton 0-2 Brentford (Carabao Cup - September 16, 2020)
Last season, Brentford famously reached the semi-finals of the Carabao Cup.
En route to the final four, the Bees knocked out four Premier League clubs - including Southampton in the second round.
The hosts dominated possession and produced more shots on target but in the end, it was two first-half goals from Christian Norgaard and Joshua Dasilva which sealed a memorable victory for the Championship outfit.
Predicted line-up for Southampton vs Brentford
Southampton XI: Forster - Salisu, Stephens, Bednarek, Perraud - Redmond, Ward-Prowse, Romeu, Elyounoussi - Broja, A. Armstrong
Brentford XI: Fernandez - Ajer, Jansson, Pinnock - Canos, Jensen, Baptiste, Norgaard, Roerslev - Toney, Mbeumo
Stats point to strong Saints start and exciting Brentford finale
Southampton have proven to be a tough team to crack in recent months. Hasenhuttl's men lost just one of their last seven league outings - six of them in the Premier League.
But despite their ability to avoid defeats, Saints have also developed a knack for dropping points from losing positions.
This is a team which has endured six home draws this season - five of them coming after Southampton had taken the lead.
Brentford will be buoyed by that stat as the London outfit currently hold the record for the most game-winning goals this season in the last 10 minutes of games - three in total.
Last 10 meetings
Southampton wins: 5
Brentford wins: 2
Southampton goals: 17
Brentford goals: 10
Keep your eye on Brentford's hat-trick hero
With around 30 minutes remaining of their FA Cup clash with Port Vale, the Bees were only 1-0 ahead against the League Two outfit.
Thomas Frank needed to strengthen that advantage and decided to throw on Bryan Mbeumo for the final stage of the tie.
The Frenchman duly delivered as he bagged a 29-minute hat-trick on his return from injury.
With a performance like that, you can expect the 22-year-old to start against Southampton.
Speaking of the Saints, the man to keep an eye on is James Ward-Prowse.
The 27-year-old is in a goalscoring mood at the moment, having found the back of the net in three successive Premier League games.
If that wasn't enough, the Saints skipper has also produced two assists in his last three outings.