The 30-year-old has been training away from the group this week after being laid low by illness and will be assessed before Howe names his team.
Midfielder Ryan Fraser joins fellow calf injury victims Paul Dummett and Matt Ritchie, Emil Krafth (knee) and Alexander Isak (thigh) on the sidelines.
Graham Potter will hope to have Jorginho available for the trip to Tyneside.
The midfielder took part in training, but otherwise Potter continues to deal with a number of injury problems.
Ben Chilwell (hamstring), Reece James (knee), Kepa Arrizabalaga (foot), N'Golo Kante (hamstring) and Wesley Fofana (knee) miss out.
Newcastle provisional squad: Pope, Darlow, Trippier, Murphy, Manquillo, Targett, Lewis, Botman, Burn, Schar, Lascelles, Shelvey, Guimaraes, Longstaff, Joelinton, Anderson, Almiron, Wilson, Wood, Saint-Maximin.
Chelsea provisional squad: Mendy, Azpilicueta, Chalobah, Thiago Silva, Cucurella, Loftus-Cheek, Jorginho, Sterling, Havertz, Mount, Aubameyang, Bettinelli, Kovacic, Pulisic, Broja, Zakaria, Ziyech, Gallagher, Koulibaly, Hall.