The opening weekend of the Premier League season saw contrasting fortunes for the two Manchester clubs and that has been reflected in Planet Sport Bet's markets.
Following their 1-0 defeat at the hands of a Harry Kane-less Tottenham, City have drifted out to 11/10 from 8/11.
Spurs, in contrast, are now 7/2 for a top-four finish, from 9/2.
United, meanwhile, are in to 6/1 from 13/2 to win the Premier League after their Paul Pogba-inspired dismantling of Leeds United - odds that will come as something of a shock to United fans who believe they have already won it.
Chelsea, who eased to a 3-0 win over Crystal Palace, are now 7/2 from 4/1, while Liverpool, who will be hoping history repeats itself after a 3-0 win at Norwich, are now 4s (from 9/2) - the Reds beat Norwich on the opening day on their way to the title in 2019/20.
Mo Salah was one of the Liverpool scorers on Saturday and his goal, combined with Kane's absence at the Tottenham Hotspur Stadium, has resulted in the Egyptian becoming the solid 4/1 favourite to the Premier League's top scorer.
At the other end of the table, Planet Sport Bet are predicting another long, miserable Premier League season for Daniel Farke's Canaries, with Norwich now clear 8/11 favourites to be relegated.
There is better news for another of the promoted clubs, however, with Brentford having moved out to 9/4 from 15/8 to be relegated following their 2-0 win over Arsenal, a victory which has seen increased support for Mikel Arteta to be the first top-flight manager to leave their post. Arteta is now 11/4 favourite. You can also get 33/1 on Arsenal to be relegated.
Sports Personality of the Year
Having had his price slashed to win Sports Personality of the Year after his Olympic golds, Adam Peaty has seen his odds tumble even further with the announcement he will be taking part in Strictly Come Dancing.
The Great Britain swimmer can be backed at around 7/1 for SPOTY after swapping leg kicks for heel flicks.
Tom Daley, who is surely a cert to go from diving to jiving in the near future, remains 2/1 favourite, while Joe Root who is almost single-handedly taking on India for England, is 66/1.
US Open tennis
The absence of Roger Federer due to knee surgery means Novak Djokovic, already an odds-on favourite - has shortened to 8/11 from 4/5 to win next month's US Open.
Federer, who recently turned 40, is unsure whether he will be able to return to the top level when he returns but says he wants to "return to the tour in some shape or form".
There are doubts about Djokovic's form heading into the Major however, with the Serb having opted not to play any warm-up events.
Djokovic failed to medal at the Olympics and probably needs the extra time to replace all the rackets he lost or smashed in the process.