The former powerhouse of English football has now kicked off the new Premier League campaign with back-to-back defeats after falling to Brighton at home the weekend prior.
Interestingly, this is the first season since the inaugural year of Premier League football that a United team has lost successive opening fixtures.
On that occasion, Sir Alex Ferguson's men were beaten 2-1 at Sheffield United before facing a 3-0 hammering at home against Everton.
That result left the Red Devils at the foot of the Premier League table for three days, before recovering in fine style and winning the title.
Barring a heavy defeat for Nottingham Forest or West Ham on Sunday, or Crystal Palace on Monday, Erik ten Hag's men will likely remain at the bottom of the standings until next weekend.
However, with their opponents being Liverpool, that position may last longer than most fans can bear to witness.
Liverpool have won the last three head-to-head league meetings and boast an aggregate score of 13-2.
The one small positive for United fans is the fact the Red Devils did enjoy a 4-0 win over the Reds during pre-season.