The FA have announced that England manager Sarina Wiegman will be absent from the Friday night's Northern Ireland match after testing positive for Covid-19.
England currently sit top of Group A after consecutive wins against Austria and Norway, and have a chance to seal their spot at the top with a victory against Northern Ireland.
But the Lionesses will have to do it without the help of Wiegman, who now faces a period of isolation.
Wiegman's assistant Arjan Veurink will instead take charge in her absence for the match at Southampton's St Mary's stadium.
"England head coach Sarina Wiegman has tested positive for Covid and will undertake a period of recovery at the squad's base camp," the FA announced in a short statement.
"Assistant coach Arjan Veurink will lead the team for tonight's fixture against Northern Ireland.
"Wiegman will remain in remote contact with the players and technical staff and will be monitored regularly with a view to returning to all elements of her role as soon as possible."
UEFA protocols state players or staff only have to test if they are symptomatic of coronavirus and, as of yet, none of the England squad have been ruled out.
England so far boast a perfect record in the tournament after a 1-0 win over Austria and a record-breaking 8-0 demolition of Norway.
The Lionesses kick-off against a winless Northern Ireland side at 20:00 BST on Friday, July 15.