The likes of Sergino Dest, Giovanni Reyna and Matthew Hoppe have shown glimpses of real potential this season, while Weston McKennie is catching the eye at Juventus.
The United States are a 60-1 shot with Paddy Power for glory at FIFA World Cup 2022 - but we will be tracking each player's progress with a weekly report and rating.
Christian Pulisic
15th February, Chelsea 2-0 Newcastle
Linking up with ex-Dortmund boss Thomas Tuchel, Pulisic continues to start on the bench for the German manager, with the likes of Timo Werner and Mason Mount offered the starting roles at the moment.
Pulisic has just two goal contributions (1G, 1A) in 15 Premier League appearances this season and, given the array of attacking talent the Blues possess, chances have been few and far between for the American.
Once again, against Newcastle, Pulisic remained an unused substitute and will have to stay patient until Tuchel grants him the opportunity to start for Chelsea.
So far, out of the possible 450 minutes of playing time under the new Blues coach, Pulisic has seen just 84 minutes of action.
Rating: N/A
READ MORE: Steve Nicol baffled by Christian Pulisic's lack of minutes at Chelsea
Tim Ream
14th February, Everton 0-2 Fulham
Ream continues to occupy the bench, unable to displace the pairing of Joachim Andersen and Tosin Adarabioyo that Scott Parker prefers currently.
The centre-back did not get on the pitch as the Cottagers picked up a shock 2-0 win away at Goodison Park.
Similarly, Antonee Robinson was an unused substitute for Fulham, with Parker choosing to surprisingly deploy Ola Aina as an inverted left wing-back instead of the American full-back.
Not including Robinson was a strange move, considering the left-back had been nearly ever-present for his side, barring his two-game suspension at the end of January.
Rating: N/A
DeAndre Yedlin
14th February, Galatasaray 2-1 Kasimpasa
Since moving to Turkey in January, Yedlin has yet to start for Galatasaray, who sit top of the Super Lig, level on points with both Besiktas and Fenerbahce.
Hosting Kasimpasa, the American full-back came on in the 77th minute, replacing Muhammed Kerem Akturkoglu.
Due to his late introduction, Yedlin didn't really have much time to impose himself on the game as the hosts collected their sixth consecutive league win.
Rating: 6/10
READ MORE: USMNT: Who will join Christian Pulisic and Sergino Dest in Qatar 2022?
Sergino Dest
13th February, Barcelona 5-1 Deportivo Alaves
With Oscar Mingeuza preferred at right-back in Ronald Koeman's four-man defence, Dest had to wait until the 72nd minute for his introduction at Camp Nou.
Shortly after, Barcelona added three goals to their tally, cruising to a 5-1 victory at home. Due to their attacking dominance, Dest was rarely called upon as the wing-back enjoyed an easy day at the office.
A small step back to action for the right-back, who was only fit enough for the bench in the last three games due to muscular problems.
Rating: 6/10
Giovanni Reyna
13th February, Borussia Dortmund 2-2 Hoffenheim
Starting on the right of Dortmund's three-man attack that supports Erling Haaland, Reyna swiftly moved inside, switching with Julian Brandt to occupy a more central role for Edin Terzic's side.
Lasting an hour before being substituted, Reyna looked a bright spark but failed to make any significant contributions as his side played out a 2-2 draw, which could leave them eight points off the Champions League places.
In the same fixture, Chris Richards, who is on loan at Hoffenheim from Bayern Munich, remained on the bench as an unused substitute.
Rating: 6.5/10
Matthew Hoppe
13th February, Union Berlin 0-0 Schalke
Playing from the start as a lone striker in Schalke's 4-2-3-1 formation, Hoppe played the entirety of the goalless Bundesliga fixture.
The 19-year-old led the line with real authority, constantly bringing the likes of Nabil Bentaleb and Amine Harit into the game and toying with the Union Berlin defence.
However, his hard work did not pay off, meaning Hoppe is now goalless in four games - last scoring against Koln to mark a run of five goals in three games.
If Schalke are to escape the Bundesliga drop, they will be reliant on the young American forward ending his baron run of form to fire them up the table.
Rating: 6.5/10
Tyler Adams
12th February, RB Leipzig 2-1 Augsburg
Replacing Kevin Kampl as a 64th-minute substitute, Adams operated as a holding midfielder to help his side to another three points in the Bundesliga.
After his second-half introduction, the versatile defensive midfielder managed just eight minutes before being booked for a nasty foul on Rani Khedira in the middle of the park.
Despite playing nearly half an hour, Adams didn't see much of the ball - completing just 17 passes - as Leipzig cruised home to a comfortable 2-1 win, in a game which wasn't as close as the scoreline suggests.
Rating: 6/10
Josh Sargent
13th February, Werder Bremen 0-0 Freiburg
Partnering Milot Rashica up top, Sargent embodied his team's struggles as he and Werder Bremen went goalless against Freiburg.
In fact, in the 62 minutes before his substitution, the 20-year-old American forward failed to have a single shot with all the attacking opportunities falling to his partner Rashica.
Werder Bremen remain 11th in the Bundesliga and will be keen to see Sargent pick up some form, given he has only scored twice in 19 appearances this campaign.
Rating: 6/10
Weston McKennie
13th February, Napoli 1-0 Juventus
Andrea Pirlo opted for a four-man defence in Naples, meaning McKennie would be competing for one of two midfield spots.
Unfortunately for the ex-Schalke midfielder, he started on the bench and had to wait until the 62nd minute for his opportunity.
McKennie impressed in his 30-minute cameo, winning 100 per cent of his midfield duels as his side attempted to chase an equaliser.
A headed chance did fall to him in stoppage time, which he wasted, heading wide to the left of goal from inside the area.
Rating: 6.5/10
Tim Weah
14th February, Lille 0-0 Brest
Lille sit top of Ligue 1 but were held to a frustrating goalless draw against 12th-placed Brest.
Weah appeared as a 61st-minute substitute, replacing Jonathan Ikone up top to partner Canadian Jonathan David.
Flicks, tricks and general link-up play in his brief 30-minute spell showed off the young American forward's talent, although he did fail to register a single shot on target to test the opposition's goal.
Scoring just three goals in 18 Ligue 1 appearances, Weah is still attempting to find his feet, however, he and his Lille team-mates continue to sit at the top of the French top-flight.
Rating: 6.5/10
Bryan Reynolds
14th February, Roma 3-0 Udinese
Reynolds did not feature in the matchday squad, still out with a slight knock as Roma eased to a 3-0 victory to lift them up to third in Serie A.
Rating: N/A
Indiana Vassilev
After being loaned out by Aston Villa to League Two Cheltenham Town, Vassilev did not play at the weekend but returns to action away to Walsall on Tuesday 16th February.
Rating: N/A
