Mikel Arteta is the new favourite to be the first manager to leave his post in 2021/22 following Arsenal's surprise 2-0 defeat to Premier League newcomers Brentford.
At the end of last season, Arteta identified seven positions for his side to improve in, but actions speak louder than words, and it was the same old story on Friday night.
Sergi Canos and Christian Norgaard scored the goals, while Ivan Toney gave White and co nightmares at the back.
With both Pierre-Emerick Aubameyang and Alexandre Lacazette absent through illness, the Gunners lacked firepower up top, and only managed four shots on target.
After a dire opening day performance against the Bees, Arsenal are anything but buzzing with Arteta, and he is now odds on to be the first Premier League manager to lose his job at 11/4.
Pep Guardiola, despite Manchester City's opening-weekend defeat, is still seen as the least likely manager to leave their post first. The Spaniard is 66/1 to be the Premier League's first casualty of the campaign.
Planet Sport looks at the rivals to Arteta at the head of the Next Manager to Leave Post betting.
Patrick Vieira - 5/1
Relatively inexperienced in the managerial hot seat, the new Crystal Palace manager is under heaps of pressure to succeed with the Eagles.
The Frenchman's only previous experience came as boss of New York City, as well as a recent two-year stint at Nice.
Vieira enjoyed a successful start to life as manager, as he took New York City FC to their first ever MLS play-offs, but his time at Nice told a different story, and he was sacked in his second season after a run of five consecutive defeats.
The former Arsenal midfielder was handed a difficult Premier League opener away to European Champions, Chelsea, and Palace struggled to disrupt Thomas Tuchel's side as they eased to a 3-0 win.
Vieira will undoubtedly be given more time to implement his style at Selhurst Park, but with pressure already mounting, he is valued at 5/1 to be the first manager dismissed.
Xisco Munoz - 7/1
However, even with three points under his belt, Watford boss Xisco Munoz is still among the favourites to be handed his P45.
The Hornets are no strangers to hiring and firing managers. Since taking over the club in 2012, the Pozzo family have had 14 different permanent bosses.
Additionally, Watford are among the favourites for relegation, and if Munoz suffers a poor run of results, it's well known that there will be no hesitation in pulling the trigger over his dismissal.
Steve Bruce - 9/1
Despite guiding Newcastle United to Premier League safety in 2020/21, it appears that Steve Bruce's impressive run during the tail-end of last season has been quickly forgotten about, and he remains among the favourites to be sacked.
Bruce's Magpies started their campaign brightly, as Callum Wilson opened the scoring against West Ham United, but a second half onslaught from the Hammers doomed Newcastle to a 4-2 loss.
Not a great start, but with plenty of games left to play, Bruce will hope the £25million signing of last season's loan-star Joe Willock will help him defy the odds once more.
Premier League sack race odds
Mikel Arteta (Arsenal) - 11/4
Xisco Munoz (Watford) - 7/1
Ralph Hassenhuttl (Southampton) - 8/1
Steve Bruce (Newcastle United) - 9/1
Sean Dyche (Burnley) - 12/1
Bruno Lage (Wolverhampton Wanderers) - 14/1
Daniel Farke (Norwich City) - 14/1
Dean Smith (Aston Villa) - 16/1
Graham Potter (Brighton and Hove Albion) - 20/1
Thomas Frank (Brentford) - 33/1
No manager to leave - 80/1