Further bad news for Man City and Pep Guardiola after opening-day defeat
History suggests City are unlikely to retain their title after a loss in their first match of the campaign but it is good news for Chelsea, Man Utd and Liverpool.
Manchester City's title defence got off to the worst possible start at the weekend when they went down 1-0 to Tottenham.
One match doesn't make a season (despite what Manchester United fans might think) but are we able to garner anything from the results from gameweek 1? Well, yes.
Planet Sport has looked through every Premier League season opening weekend to see how the eventual champions fared.
Not since Manchester United in 2013 have the champions not won their first game - Sir Alex Ferguson's last title triumph saw them lose their opening fixture to Everton.
Indeed going into the 30th Premier League season, only nine times have the champions not won their opener. And bad news for Manchester City, only three times have the eventual champions lost their first game.
92/93 Manchester United
93/94 Manchester United
94/95 Blackburn Rovers
95/96 Manchester United
Another title win for United but another less than perfect start, as they went down 3-1 at Aston Villa. This was the famous you don't win anything with youngsters synopsis from Alan Hansen. Oh how wrong he was.
96/97 Manchester United
98/99 Manchester United
Sir Alex Ferguson's men were back to winning ways and this was the famed treble season, but again their start wasn't great as they drew 1-1 at Leicester.
99/00 Manchester United
Another title, another opening day failure - this time as they drew at Everton.
00/01 Manchester United
Better from United this time as they opened up with a 2-0 win over Newcastle at Old Trafford.
A near-perfect start for Arsene Wenger's men as they romped to a 4-0 success at Middlesbrough.
02/03 Manchester United
Jose Mourinho's first season was a great one as they won the title conceding just 15 goals in the process. And it all started with a brilliant opening success over Manchester United.
06/07 Manchester United
07/08 Manchester United
08/09 Manchester United
Carlo Ancelotti enjoyed his first season at Chelsea with the title win which began with a comfortable opening-day success against Hull City.
10/11 Manchester United
11/12 Manchester City
12/13 Manchester United
13/14 Manchester City
15/16 Leicester City
Leicester's most unlikely of title triumphs began with a victory over Sunderland in their opener.
Chelsea's last title success came after an opening-day win over West Ham.
17/18 Manchester City
18/19 Manchester City
The Reds claimed their first ever Premier League title, and it all began with a big win over Norwich - their opening-game opponents this time around.
20/21 Manchester City
Back to winning ways for Pep's men earlier this year and it came after an opening success at Wolves.