After last weekend's match-up against Man United was postponed due to fan protests, Liverpool now face a hectic end to the 2020/21 Premier League campaign.
With five games left to play, Liverpool sit seven points adrift of Chelsea in fourth place, albeit with a game in hand.
This weekend they take on Southampton, who are currently 15th in the table and without a win in their last four games.
Tip for the fixture
Salah has seven goals in seven appearances against Southampton, and looks a good bet to improve on that at the weekend. Sky Bet are offering odds of 11/10 for Salah to score and Liverpool to win.
Before this season, Liverpool had won their last six fixtures against Southampton. However, at St Mary's earlier this season they were defeated 1-0 by the hosts.
Southampton have not scored a goal at Anfield in their last four trips there. The last time they did score, they won 1-0 in the League Cup in 2017.
Salah has faced the Saints seven times, and he has scored in five of those fixtures, including two braces.
Here, we take a closer look at Salah's last three appearances against Southampton at Anfield:
Liverpool 3-0 Southampton (November 18, 2017)
Salah was the star man in his first appearance against Southampton as his brace helped Liverpool win a comfortable three points.
The Egyptian opened the scoring after half an hour with a superb effort from just outside the box which curled into the top corner, leaving keeper Fraser Forster no chance.
Ten minutes later Salah had his second, racing onto a through ball from Philippe Coutinho, and first-time he poked the ball past Forster and into the back of the net.
Coutinho got Liverpool's third and final goal. And, in truth, Salah could easily have got himself a hat-trick with five shots throughout the game.
Salah terrorised the Saints defence and thoroughly deserved the Man-of-the-Match award.
Liverpool 3-0 Southampton (September 22, 2018)
Once again Liverpool dominated Southampton at Anfield, with all three goals coming inside the first half.
The Reds found themselves two up after just 20 minutes thanks to a Wesley Hoedt own goal and a Joel Matip header, and Salah sealed the deal just before the half-time whistle.
Xherdan Shaqiri's free-kick rattled the crossbar, but Salah was first to the loose ball and tapped into an open net to make it three at the break.
It was another brilliant performance from Salah, and just like the season before he could have easily scored a couple more having missed two big chances early on.
Liverpool 4-0 Southampton (February 1, 2020)
Liverpool bested Southampton yet again last season with Salah scoring two of his side's four goals.
The teams entered the half-time break with the score still goalless, but when Alex Oxlade-Chamberlain found the net two minutes after the restart the floodgates opened.
Jordan Henderson doubled the Reds' lead after an hour of play, and ten minutes later Salah finished an opportunity to make it three.
Salah beat Saints keeper Alex McCarthy to a through ball from Henderson and, from just outside the six-yard box, poked the ball in at the near post.
In added time he got his second after some lovely link-up play with Roberto Firmino.
Like every previous game at Anfield against this opposition, Salah was too much for the defence to handle, and as well as scoring two he was at the heat of several other chances.