Manchester United bounced back from their Liverpool humiliation to beat Tottenham 3-0 last weekend and Cristiano Ronaldo netted again to reward his owners, but the result also saw the end of Nuno Espirito Santo.
After just four months in charge, the Portuguese boss was sacked and replaced by Antonio Conte, and the arrival of the Italian has sparked interest in a number of Spurs assets, including Harry Kane.
With a fresh week of problems to fix, and new choices to make, we answer five topical questions ahead of the Gameweek 11 deadline.
Will Antonio Conte revive Harry Kane's season?
It goes without saying that Harry Kane has performed well below par this season in the Premier League.
The three-time Golden Boot winner has just one goal to his name after 10 games this season, and has looked far from his usual self.
Of course, that can mostly be attributed to the fact that he doesn't want to be there. Kane clearly wanted to make a switch to Manchester City this summer, but a breakdown in negotiations has left him stranded in north London.
Uninterested and therefore underperforming, Kane often looked like a passenger under Nuno Espirito Santo, but after the Portuguese manager was sacked this week, could Kane's season be turned around?
Antonio Conte's appointment has been the week's major talking point and the Italian manager is famed for being highly demanding of his players.
It suddenly makes Kane an exciting prospect for Fantasy Premier League managers looking to get an advantage over their rivals.
Sure, Kane's £12.1million price tag is hefty, but with Cristiano Ronaldo spearheading Solskjaer's shaky Manchester United side and Romelu Lukaku remaining on the sidelines, there's a lack of in-form strikers out there. Kane could be a great option as he looks to impress his new Italian boss.
Can Cornet continue carrying the Clarets?
One of the signings of the season is Maxwell Cornet, who has already justified his £12million transfer fee since moving from Lyon in the summer.
The Ivorian was brought to Turf Moor to energise a Burnley front three that was beginning to go stale and he's shone in claret and blue.
Despite featuring in just five games this season, Cornet has scored four goals from midfield, helping him to an impressive 32 points.
With just a £6million price tag, he's beginning to look like a fantasy bargain for managers needing a boost in midfield.
However, his injury record may dissuade any tempted managers - Cornet has already missed a handful of games this season for Burnley, so owning him runs the risk of inconsistent points scoring.
But his cheap value means he can easily be replaced if necessary, and his form is too good to miss out on at the moment.
Admittedly, Burnley's trip to Chelsea next weekend means this may not be the best time to bring in Cornet, but he has certainly earned a place on our watchlist, and could even be worth gambling on this week.
Both Ashley Barnes and Chris Wood have failed to get going and Cornet looks like Burnley's best - if not only - route to goal.
If Sean Dyche's side are to cause an upset in London on Saturday, the 25-year-old will likely be involved.
Can Jarrod Bowen keep providing for the Hammers?
Their most recent win came against Aston Villa to make it four from five in the league, and once again Jarrod Bowen popped up to score points with a goal and an assist.
His season started slowly with just nine points in his opening four games, but since then the English forward has bagged 37 in his last six, including 11 against Villa.
Bowen is also an incredibly reliable figure in the West Ham team, missing only 21 minutes this season.
Despite Michail Antonio's drop in points of late, the Hammers show no sign of slowing down in the league, and Bowen might be the latest route to ensure you profit from their success.
His £6.3million price tag is incredibly cheap considering he's the 10th-highest scoring midfielder this season, and he's only owned by 1.5% of teams.
Liverpool, Wolves and Manchester City don't make the easiest next three fixtures for West Ham, but Moyes' side have already proved capable of scoring against bigger sides this season.
Reece James or Ben Chilwell?
Another week, another Chelsea clean sheet. Thomas Tuchel's side shut out Newcastle this time around and have only conceded three goals in 10 games.
Without Romelu Lukaku, all eyes have turned towards Chelsea's defence, and it's clear to see why. But what many are wondering is, which defender is the best option?
Well, with Chelsea favouring a five-at-the-back system, their wing-backs offer the ability to score points in attack as well as benefit from clean sheets.
And both Reece James and Ben Chilwell have been superb for the Blues this season. James (£5.7m) is the cheaper of the options and has recently taken Trent Alexander Arnold's crown as the highest scoring defender following his brace against Newcastle.
His 56 points leads the way, but Chilwell is not far back with 43 and has achieved his tally in just four games.
That leaves Chilwell with an average of 10.75 points per game to James' eight.
However, recent form suggests James may be the better option, especially after scoring twice against Newcastle last Saturday.
So, as the cheaper and more reliable option, James gets our nod over Chilwell, but both are superb assets to own at the moment. To add to their attraction, Chelsea's frugal defence face Burnley next week, so the possibility of another clean sheet is high.
Is Aaron Ramsdale now the most valuable goalkeeper?
But the 23-year-old goalkeeper has proved to be an inspired addition to Mikel Arteta's side, and has created a solid foundation for a new-look Arsenal defence.
His unimpressive record at Bournemouth and Sheffield United left many wary about his chances of even starting at the Emirates, but Ramsdale has silenced his critics with four clean sheets in just seven appearances.
That's taken his fantasy total to 39 points, making him the fifth-highest scoring goalkeeper behind Lloris, Martinez, Alisson and Mendy.
However, after his superb showing against Leicester - including that save from James Maddison, Ramsdale has shown his ability to score bonus points too, and he could quickly find himself climbing the points table.
Especially with Watford and Newcastle in their next three fixtures. The trip to Anfield in between looks a lot less enticing, but it doesn't stop Ramsdale from becoming a fantastic option over the next few weeks.