Reigning Super Bowl champions, Tampa Bay Buccaneers, managed a win in the season opener vs the Dallas Cowboys on Friday, and now we can look forward to a Sunday packed with football.
Star quarterback, Tom Brady, showed no signs of rust against the Cowboys, throwing for 379 yards and registering an impressive four touchdowns.
Now he hands the baton over to Kansas City Chiefs quarterback Patrick Mahomes, who faces a tough task against the Cleveland Browns on Sunday night.
Aaron Rodgers is also back in action with the Green Bay Packers as they travel to New Orleans, while the Vikings face the Bengals and the Dolphins face the Patriots to round off our Sunday selection.
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Cleveland Browns @ Kansas City Chiefs
The Kansas City Chiefs are Super Bowl favourites and my pick for the AFC, but they face one of their biggest tests right out of the gate with the well-fancied Cleveland Browns' annual hype training rolling into Arrowhead.
The Browns came pretty close to springing the upset in their play-off game here back in January, and that experience is part of the reason why big things are expected from Baker Mayfield and company this season.
And, with Odell Beckham back at receiver alongside Jarvis Landry, the mighty running back partnership of Nick Chubb and Kareem Hunt and talented tight ends Austin Hooper and David Njoku then scoring points should not be a problem.
Against a Chiefs defence that was the worst in the red zone last season, the Browns' attack is just slightly being undervalued and can post over 24.5 points at Evens.
Amazingly, the Browns haven't won a season opener since 2004, obviously the worst run in NFL history, but after snapping their 12-year run of losing seasons and 17-year-old playoff drought last season, this would be an even bigger achievement given the opposition.
I'm not quite there yet with the Browns, although it wouldn't be a huge surprise if their fierce defence including the imposing Myles Garrett got the better of a totally revamped offensive line for the Chiefs.
After watching Patrick Mahomes get dominated in the Super Bowl, Kansas City have acted and veteran left tackle Orlando Brown has had some success snuffing out Garrett's threat - holding the former No.1 pick without a sack in the one game he played him last season.
So, enough to suggest that Mahomes will have enough time to do what he does best and put points on the board quickly - so the over 53.5 total points spread at 4/5 looks easily attainable.
The Chiefs can always run away with a game, but the Browns have all the tools to keep this game close. They have a tough defence but they can also lean on that string run game to keep Mahomes off the field and take time off the clock - it may not be enough, but it could keep it close.
Minnesota Vikings @ Cincinnati Bengals
Dak Prescott returned from serious injury in fantastic fashion for the Dallas Cowboys on Thursday, not Joe Burrow will try to do the same for the Bengals as they host the Vikings looking for an upsurge in fortunes this season.
What we do know is that Burrow is definitely a franchise quarterback as he was excellent before he went down injured last season, and he'll return to face a Vikings secondary that gave up plenty of big plays last season.
Burrow displayed poise, leadership and arm talent in his rookie year, and although he had a big ACL injury the stats prove that quarterbacks actually enjoy a slight rise in completed passes and rating when returning from such injuries.
And the No.1 draft pick should respond, and Bengals coach Zac Taylor's top priority is keeping him safe, so look for the team to run the ball and go for short safe passes to get the ball out of Burrow's hands quickly.
On defence they'll face all-action Vikings running back Dalvin Cook who can feast on the soft defensive front the Bengals had last season when they yielded over five yards per carry up the middle - the worst record in the AFC for nine years.
The Vikings conceded 40 points per game in their last three games last season, but they'll be tighter to start this campaign, and with both teams looking to run and a conservative Bengals gameplan, this should be a relatively low-scoring close game.
Minnesota are generally three-point favourites but with home advantage the Bengals could actually take this game and looking at the odds I'm going for them to take this one straight up.
The home field advantage will be back in full force this season and that coupled with it being the first game of the campaign and Minnesota's revamped secondary Cincinnati can start the new Burrow rein with a victory.
Green Bay Packers @ New Orleans Saints
Obviously football isn't the most important thing going on in New Orleans right now, but how the Saints would love to have played this game in their own Superdome, which is one of the loudest venues in the NFL and offers up a huge home advantage.
Instead, due to the damage done in New Orleans by Hurricane Ida, this game will take place in Jacksonville and that instant gives the Packers more of an advantage.
They're 3.5-point favourites and that's more than fair given the Saints have lost home advantage, lost star quarterback Drew Brees, and lost some big players to retirements and cuts due to a salary cap squeeze. They'll have 10 new starters at least.
Jamies Winston is the man stepping in for Brees at QB, but watch for Taysom Hill, who is a QB but can line up as a running back, receiver or tight end and produce some eye-catching highlights. He's the Swiss army knife of the NFL.
Winston can make all the throws but needs to cut out the big mistakes, and the Saints do have Alvin Kamara - their star running back and one of the best in the league who had a huge game against Green Bay last season setting career best marks in total yards (197), receiving yards (139) and receiving touchdowns (two).
While New Orleans have lost their Hall of Fame quarterback, the Packers still have theirs - just - after Aaron Rodgers called off his feud with the team officials and although this could well be his Last Dance season, it could very well be a huge one.
I've backed them to go all the way in my season preview, and part of the reason is that Rodgers, like all great sports stars, plays their best when they have a point to prove. He had one last season and put in an MVP season, he's got a bigger one this year, so watch out!
Miami Dolphins @ New England Patriots
New England used to rule this division, but since Tom Brady left they're now seemingly scrapping with the Dolphins for the hope of a wildcard place this season. It must drive Pats coach Bill Belichick crazy and he'll be out to prove a point this season.
It'll start with him having a dastardly defensive plan for second year QB Tua Tagovailoa - who at 23 is looking to be the youngest visiting QB to win at Gillette Stadium. Quarterbacks his age or younger are 1-20 at the venue.
Tua does have rookie receiver Jaylen Waddle to throw to this season, and watch out for a big year from him, but this game will be more about defence than attack - with the Patriots starting rookie Mac Jones at QB. No pressure then stepping into Tom Brady's shoes...
The Dolphins' defence led the league in turnovers last season so Jones could be in for a tough game, while Tua will face pressure all round with Belichick having all summer to scheme a way to keep him in check.
Teams were successful when throwing to their running backs against the Patriots last season, so Tua will be looking to Myles Gaskin pretty often - and he could a difference maker in a close hard-fought contest.