Los Angeles Chargers @ Philadelphia Eagles
Chargers QB Justin Herbert is facing his first real crisis in his short NFL career, as he was dominated in Baltimore and then put well off his stride by Bill Belichick's Patriots last week. While those two things can happen to any young quarterback, it's important Herbert hits back on the long trip east to Philly.
Herbert averaged just 209 yards a game with three TDs but three interceptions over those two defeats and will need to improve those numbers quickly against the Eagles, who LA need to get ahead of and make them play catch-up.
That's because the Eagles bust out into full-on smashmouth running football mode against Detroit last week, which is unfortunate timing as the Chargers allow a league-worst 160 yards rushing per game. Philly tallied 236 yards and four rushing scores against the Lions.
Boston Scott had a big game and will fancy his chances again of cashing in, while QB Jalen Hurts should get a few more yards as he's run for 30 or more in 12 straight games.
And yet, that rushing approach won't work if Herbert and the Chargers attack can get the first blows in and race out to a quick lead, and I think they're due a response. The game situation is everything in this one but Herbert can start fast and get LA back on track.
Arizona Cardinals @ San Francisco 49ers
The Cardinals just have to be careful here not to start letting their fantastic season slip after losing their unbeaten record to Green Bay last week. They now head to Santa Clara to tackle the Niners with injury worries over Kyler Murray and DeAndre Hopkins while AJ Green is out for the game and JJ Watt out for the season.
They're big problems to overcome against a side the Cards only beat by seven a month ago with all their star players healthy and with the 49ers without Jimmy Garoppolo. And it'll be a jacked-up Jimmy G they'll face after he had a day in Chicago last week with 322 passing yards and two rushing touchdowns.
Having tight end George Kittle back could be huge for the Niners if he's up to speed, and given their injuries then Arizona's own tight end Zach Ertz could well have a big day himself. Ertz has 108 yards from seven catches and a TD in his two games with his new team, and he'll only get better.
Watch out for one or both of the tight ends scoring a touchdown here, with Christian Kirk now the top wide receiver option for the Cardinals if Hopkins can't go.
It's an intriguing clash given all the injury problems, but even with the losses you don't become a bad team with just one loss, and Arizona have already shown multiple ways to win football games. So getting odds-against on a 7-1 team with so much talent is a bet you just can't pass up.
Tennessee Titans @ Los Angeles Rams
It's all about additions and takeaways in LA this Sunday, as while the ambitious Rams and their gung-ho GM Les Snead made yet another blockbuster trade aimed at a Super Bowl run, the Titans lost their star man and perhaps their own chances of glory.
The Rams are always seemingly in win-now mode and don't mind throwing draft picks away in trades for big-name players, and adding pass rusher Von Miller to Aaron Donald and this Rams defence does indeed elevate that unit into elite status.
That unit won't have to face Titans running back Derrick Henry either, who has been in a league of his own as the double defending rushing champion, and was on pace to make history this season before injury cruelly cut his campaign short.
To put Henry's importance into perspective, the Titans haven't won a game without Henry on the field since 2015! Even if they've brought in the legendary Adrian Peterson, the veteran won't be able to fill the hole left by the King.
Tennessee will still be able to run the ball as their offensive front made the holes for Henry to power through, but Peterson and Jeremy McNichols may not be able to keep up if Matthew Stafford has his way with the Titans secondary.
The Rams average the most passing yards per game to wide receivers in the league (253), while the Titans allow the most passing yards per game to wide receivers (216). So it's not hard to work out what will win this game for the Rams.
Stafford is already 11/2 second favourite for the MVP but I fancy him to put on a clinic here and those odds may be cut a bit come Monday morning after a big showing in a primetime game.