The third trial run of sprint qualifying will see the sessions take on a radically different structure, with three days of meaningful action to watch, and markets to match.
A standard qualifying session will take place on Friday, with the sprint on Saturday setting the grid for Sunday's main event.
Max Verstappen took a commanding victory last time out in Mexico, as he leapt past both Mercedes cars at the start, and subsequently took control of proceedings for all 71 laps, on a track where Red Bull had been expected to dominate.
These were ominous signs for Lewis Hamilton and Mercedes, as the reigning World Champion admitted he simply couldn't keep up with the faster Red Bull, making him fall 19 points behind his title rival heading into the final four races.
Brazil will be a must-win race for Mercedes, then, as Hamilton looks to claw his way back into title contention. Whether or not he and his car will have enough speed to overhaul Red Bull, however, is another matter.
(All text odds correct at time of publication, the ones in the blue boxes are bang up-to-date)
Planet Sport Brazilian GP betting picks
Alongside the usual offering, Planet Sport Bet is offering a market on the winner of Saturday's sprint qualifying session.
Verstappen is evens to be the fastest qualifier on Friday, which represents a better price than his 8/11 odds on winning the 100km sprint qualifying race.
Having a race over only 24 laps will throw up more variables, and Hamilton's price of 2/1 to win the sprint is not beyond the realms of possibility.
Valtteri Bottas has been in excellent form in qualifying and started on pole in Mexico, and he's 13/2 to come out as fastest qualifier on Friday.
Other Sao Paulo GP value bets
Pierre Gasly was in superb form to finish fourth in Mexico, and he took a podium finish at the last race in Brazil in 2019. He's available at 5/1 to finish in the top three on Sunday.
Kimi Raikkonen took a well-earned points finish in Mexico, and he is 7/4 to repeat that feat this weekend.
Bottas was the sacrificial lamb for Hamilton after being spun at the first corner in Mexico and was deployed to take the fastest lap from Verstappen at the end of the race.
If he finds himself in a similar situation and being out of contention again, he's 5/1 to record the fastest lap of the race.
When will the action take place? (All times GMT)
Practice 1: Friday 12 November, 3.30pm-4.30pm
Qualifying: Friday 12 November, 7pm-8pm
Practice 2: Saturday 13 November, 3pm-4pm
Sprint qualifying: Saturday 13 November, 7.30pm
Race: Sunday 7 November, 5pm
How do I watch?
The race is broadcast live on Sky Sports F1 in the UK, and the build-up begins at 3.30pm on Sunday.
Extended highlights are shown later that night on Channel 4 from 11pm.