The reigning Superbowl champions were in action on Sunday night, as Tom Brady's Buccaneers took on the Philadelphia Eagles.
It turned out to be a fairly routine win for Tampa Bay, with 44-year-old Brady showing his experience to secure a 31-15 win.
The Bucs found success on the ground early on, with two runs from Giovani Bernard and then Ke'Shawn Vaughn giving the home side a 17-0 lead heading into the halftime break.
They dominated the third quarter too, with Brady throwing two unanswered touchdowns to extend their lead. The first landed in the hands of tight end Rob Gronkowski, while Mike Evans was on the receiving end of a 36-yard strike shortly after.
The Eagles finally found their way to the endzone in the fourth quarter, with running backs Boston Scott and Kenneth Gainwell both putting points on the board, but it was never going to be enough to mount a comeback.
Following their win, the Bucs will now play the winner of the Rams vs Cardinals match in the Divisional Round.
Mahomes hits five for the Chiefs
After narrowly missing out on the AFC top spot, the Kansas City Chiefs faced a Wildcard match-up with the Pittsburgh Steelers.
It pitted young star Patrick Mahomes against the now-retired 39-year-old Ben Roethlisberger, but there was only to be one winner.
A scoreless first quarter set up a dramatic second which saw the Chiefs score three touchdowns in response to the Steelers' opener to leave a score of 21-7 at halftime.
Mahomes continued to find his targets in the third and fourth quarter, going on to score a further three touchdowns.
The Chiefs' 26-year-old quarterback ended the game with an incredible 404 yards and five touchdown passes.
Roethlisberger managed two of his own with 215 yards, but it turned out to be a hefty defeat in what was his final NFL outing.
49ers hold on against Cowboys
The San Francisco 49ers started superbly against the Cowboys but ended up holding on to claim a tight 23-17 win.
Elijah Mitchell completed a short sprint to the endzone in the first quarter, and three field goals gave the visiting side a 16-7 lead at halftime.
The 49ers found success in their running game again after the break with Deebo Samuel forcing his way in for six, but Jimmy Garoppolo wasn't able to add more points to the board, ending with no touchdown throws and one interception.
Dak Prescott ran a touchdown himself to claw the Cowboys back into it in the fourth quarter, but they ran out of time to find another, meaning the 49ers will now play the Green Bay Packers in the Divisional Round.