The four-time Formula 1 champion, who retires at the end of the 2022 F1 season, is also the last driver to have won the race when it last happened in 2019. The 2020 and 2021 races were cancelled due to the Covid-19 pandemic.
Vettel's five victories happened in 2011, 2012 and 2013 with Red Bull and then he won twice with Ferrari in 2015 and 2019.
The 35-year-old German has struggled all season in his woeful Aston Martin and despite this Vettel is hoping for an improved weekend's racing at one of his favourite places on the F1 calendar.
"I have many fantastic memories of racing at Singapore - I have always loved the challenge that the track provides," Vettel said.
"It is a proper street circuit - totally relentless, with corner after corner, and some incredibly fast sections. Getting on top of that challenge is incredibly satisfying - especially in qualifying.
"We should perform better here this weekend due to our car's strengths in slower-speed corners."
Aston Martin technical director Dan Fallows has confirmed the AMR22 will get some added upgrades for the Singapore weekend.
"As part of a programme to reduce the weight of the car, and improve the aerodynamic performance, we have some new items for Singapore," Fallows said on the team's website.
"It's about making the car faster but it's also about next year's car," Fallows added. "It's so important to keep bringing developments to the car and not waste any opportunity to test them on the track. You can have as much faith as you like in your wind tunnel and CFD tools, but the real answer is what happens on track.
"For us to build confidence in what we're doing for '23 - in the direction we're going - we need to keep bringing updates to the track," Fallows said. "The response from the drivers about the changes we have made this season has been good and we've seen improvements in the performance of the car too, so it shows we're on the right trajectory."
The innovative rear wing, which Aston Martin introduced at the 2022 Hungarian Grand Prix, will make a return this weekend, according to Fallows: "The Marina Bay Street Circuit should suit that wing so it's likely to be back on the car for the Singapore Grand Prix."