The Mexican driver is in good form having recently won in Singapore, grabbed a second place in Japan and finished fourth last weekend in Austin.
The Autodromo Hermanos Rodríguez track is where Red Bull have done well in the past, having won three times since 2015 and Perez certainly knows his way around the track as does his teammate Max Verstappen.
In an interview with media, Perez admitted he would love to get the victory in Mexico City on Sunday, and said: "Of course, I want to win this weekend - this is my target, this is the target for everyone who is sitting here and coming to this weekend, also for Max [Verstappen] - so we are all very competitive and we all want to get the victory on Sunday, so we're going to give it all we possibly can to achieve that," he said.
"I've dreamed a few times already about it, and it would be massive for me. Obviously, that's the target for Sunday. It will not be easy. We need to be perfect throughout the weekend, so I think all the focus will be now on the racing stuff to try to maximise the weekend," Perez said.
F1 confirmed on Thursday that the Mexican Grand Prix would remain on the calendar until 2025, which will keep Mexico City as the host.
A delighted Perez said: "This is something great for our country, you know, because this country, we get to show how good the Mexicans are, our Mexican people, our country.
"Formula 1 gives you that exposure worldwide. I'm super proud of my country that we are able to secure another contract with Formula 1, so yeah, super happy," Perez added.