Defending World Champion Max Verstappen once again showcased his supreme talent last weekend as he stormed to a fourth consecutive race win - this time in front of his home support at Zandvoort.
The win is Verstappen's 10th of the 2022 season and sees him take a 109-point in the Drivers' Championship, over Ferrari's Charles Leclerc and Red Bull team-mate Sergio Perez.
Red Bull now enjoy a commanding 135-point advantage over second-placed Ferrari, while Mercedes are a further 30 points adrift.
Asked about the Championship situation, Horner conceded that it would be quite the implosion if Red Bull somehow managed to squander their lead in the remaining seven races on the calendar.
"We're in a great position," said Horner, as quoted by F1's official website.
"And we probably have to try quite hard to lose it. But mathematically, nothing is done until it's done.
"Our approach is as it's always been - go one race at a time. Next race, next Sunday, same effort. We don't allow ourselves to think too far ahead."
Next up for Formula 1 is the highly-anticipated Italian Grand Prix at Monza, which will take place on Sunday, September 11.