Frankie Dettori will once again be onboard red-hot unbeaten favourite Inspiral (2/7), who he has ridden to four of her five victories.
The John and Thady Gosden-trained three-year-old filly scored an impressive victory in the Coronation Stakes at Royal Ascot and will be looking for a third Group 1 victory.
The 1,000 Guineas runner-up Prosperous Voyage is likely to be Inspiral's biggest challenger. The race will also feature Andrew Balding's Sandrine, who won last year's Duchess of Cambridge Stakes, Ed Walker's Primo Bacio and French raider Sibila Spain who won the Group 2 Prix du Muguet for trainer Christopher Head in May.
Chris Richardson, managing director for Inspiral's owner Cheveley Park Stud, is delighted Dettori will be onboard in a race that is part of the Qipco British Champions Series.
He said: "All through the spring Frankie was saying, 'she's not there, she's not there', and we listened to what he had to say.
"We took a long-term view and looked to the Coronation Stakes, which is one of (Cheveley Park owner) Patricia Thompson's favourite races, having won it three times before. We waited until she was cherry ripe and we were rewarded when she won impressively.
"Inspiral hasn't done much since then, but all has been well with her and she enjoyed a nice stretch on Saturday with Robert Havlin on board.
"Frankie knows her well, having ridden her in all her races bar her first, and Mrs Thompson is pleased that John (Gosden, joint trainer) is happy for him to ride her again on Friday.
"The Stud, and Flat racing, has always been her love, and she embraces every aspect of it."
Dettori will renew his partnership with Lezoo, one of six to tackle the Duchess of Cambridge Stakes.
Ralph Beckett's charge was a welcome Listed winner for Dettori at Newmarket just under two weeks ago and the pair go for Group Two gold this time.
Albany Stakes runner-up Mawj looks a key player for Saeed bin Suroor, with Michael Bell's Maylandsea another Royal Ascot runner to line up, having finished second in the Queen Mary Stakes.
David Loughnane runs both Queen Olly and Carmela with Rod Millman's Tagline the other contender.
Falmouth Stakes final field
Inspiral (Frankie Dettori)
Primo Bacio (Richard Kingscote)
Prosperous Voyage (Rob Hornby)
Sandrine (David Probert)
Sibila Spain (Aurelien Lemaitre)
Duchess of Cambridge Stakes final field
Carmela (Tom Marquand)
Lezoo (Frankie Dettori)
Mawj (Ray Dawson)
Maylandsea (David Egan)
Queen Olly (Rossa Ryan)