Settled at the rear of the field under Ryan Moore, the Aidan O'Brien-trained two-year-old was patiently ridden from a relatively wide draw in stall 10.
After the final bend, Moore asked the filly to go up a gear and she answered readily, sweeping past the leaders to breeze to a facile win.
It was O'Brien's first win of the Juvenile Fillies Turf despite saddling 15 runners previously.
Meditate's victory saw her price for next year's 1000 Guineas contract, with the bookies going to 8/1 from 16s.
O'Brien confirmed a Classic campaign is uppermost in his mind after the daughter of No Nay Never successfully stepped up to a mile for the first time.
He said: "The last twice she was beaten at the Curragh and Newmarket, she encountered bad ground in Ireland and then I think the other race came a bit quick for her, so there were genuine excuses.
"After that in her training, I gave her every excuse not to come here but she kept passing all the tests.
"We were thinking of bringing a filly called Never Ending Story over for this race but Michael (Tabor, part-owner) felt this was the right race for Meditate.
"Ryan rode her to get the trip and I will now train her for the Guineas. Ryan said he would rider her more patiently which is exactly what he did and she looked very high class.
"She's by No Nay Never who is a big influence on speed, but with the No Nay Nevers, we were a little bit worried they all might end up being sprinters, while mindful that they could stay further.
"Looking at this filly today, she's a good mover has a good mind and relaxes very well."
Moore was also impressed with Meditate's performance.
He added: "She was always comfortable having started well. There was bit of speed beside us, but the pace steadied round the bend when I worked her out wide and she went up to them very quickly and I knew I had a lot under me well over furlong out.
"I felt she was a level above them and hopefully there will be more to come."