Following an exciting opening night in Cardiff, it's Snakebite who leads the way in the competition after going all the way in the Welsh capital.
The Scot enjoyed more success during last weekend's Players Championship and will be hoping to continue his momentum in the latest instalment of the Premier League.
However, with the other seven players desperate to make up lost ground, we should be in for a thrilling night of darts. Here's Thursday's line-up and a closer look at all four quarter-final games.
Peter Wright vs Michael van Gerwen (19:10 GMT)
Jonny Clayton vs Michael Smith (19:40 GMT)
James Wade vs Joe Cullen (20:10 GMT)
Gerwyn Price vs Gary Anderson (20:40 GMT)
Semi-finals will start at around 21:10 GMT, while the final is expected to take place at 22:15 GMT.
Peter Wright vs Michael van Gerwen
Night two of the Premier League will see the resumption of the rivalry between Peter Wright and Michael van Gerwen.
The Scot will arrive in Liverpool on the back of a very successful weekend at the Players Championship in Barnsley.
Snakebite reached the semi-final on Saturday - before bowing out to Ryan Searle - and went all the way on Sunday, beating Gerwyn Price 8-5 in the final.
Wright has won 18 of his 20 games in 2022, including all three of his games on night one of the Premier League.
Van Gerwen, on the other hand, is yet to find his best form. The Dutchman faced early defeats at the Players Championship, losing to Daryl Gurney on Saturday before being humbled by world No. 99 Stephen Burton on Sunday.
The Green Machine has only won five of nine games in 2022 and is yet to get off the mark in the Premier League.
The three-time world champion will hope his rivalry with Wright can spark him back into life.
Jonny Clayton vs Michael Smith
Jonny Clayton reached the final on the opening night of the Premier League, but failed to turn up in the showpiece as he was thrashed 6-1 by Peter Wright.
The Welshman was given another hiding by the Scot during the Players Championship as he lost 6-0 in Saturday's quarter-final. The hangover from that defeat continued into Sunday as he lost 6-5 first up to world No. 47 Madars Razma.
Michael Smith was also disappointing during last weekend's event and will be desperate for a turnaround in front of his home fans in Liverpool.
Bully Boy will be hoping to replicate his performance against Clayton from the recent world championships which saw him prevail by four sets to three.
Their clash at Alexandra Palace has gone down in history as one of the best darting dramas of recent years. Should both players replicate that same form they showed at the worlds, we could be in for another thriller.
James Wade vs Joe Cullen
James Wade might not hit three figure averages or dazzle fans with his 180s, but the Machine is still a very dangerous player.
The world No. 4 four reached the semi-final stage on the opening night of the Premier League, but failed to get past Jonny Clayton despite threatening the Ferret in early parts of the match.
Joe Cullen, in contrast, is a recent winner of the Masters and arrives in Liverpool in better form than his opponent.
The Rockstar kicked off his Premier League campaign with a 6-2 defeat to Clayton last week, but he bounced back strongly with a quarter-final run at the Players Championship.
Finishing will be key in this contest. If Cullen can find his doubles with relative ease, Wade will be in trouble. However, you can rest assured that the Machine will punish his opponent for any missed opportunities.
Gerwyn Price vs Gary Anderson
The final quarter-final contest on night two will see a heavyweight clash between former world champions Gerwyn Price and Gary Anderson.
The two men haven't met head-to-head since June last year, when Price narrowly prevailed in a Players Championship quarter-final.
Price looked way off form during the Premier League's opening night as he fell to a 6-3 defeat against Wade in a drab contest.
Anderson, meanwhile, reached the semi-final but suffered a narrow 6-5 defeat at the hands of Peter Wright.
Both Price and Anderson enjoyed solid runs in the Players Championship over the weekend, with the Welshman reaching Sunday's final and the Scot competing in Saturday's quarter-final.
If both men are firing on all cylinders come night two, we could be in for some fireworks.
Who will go all the way?
There are a number of payers in good form, but there's only one in sensational form.
Peter Wright is flying at the moment and is without a doubt the favourite to go all the way for a second successive week in the Premier League.
Snakebite averaged 113 in last week's final against Clayton, and if he is to replicate that level of form it's hard to see who can stop him.