There are some tough battles taking place in the Granite City, with rock-bottom Gary Anderson hoping a home fixture can help him climb off the foot of the table.
Andrson takes on second-placed Joe Cullen in the night's opening quarter-final, before fellow Scotsman and current world champion Peter Wright tackles Joe Cullen.
Last week's winner James Wade faces the only man without a win so far in Michael Smith - with time running out for Bully Boy.
Our final quarter-final is a belter as Gerwyn Price takes on Michael van Gerwen with the Welshman needing a spark after a poor recent run.
Week 11 order of play
Jonny Clayton 19:10 Gary Anderson
Peter Wright 19:40 Joe Cullen
James Wade 20:10 Michael Smith
Gerwyn Price 20:40 Michael van Gerwen
Semi-finals will start at around 21:10 BST, while the final is expected to take place at 22:15 BST.
Jonny Clayton vs Gary Anderson
Defending champion Jonny Clayton sits in second after two nightly wins in what is a fine defence of his title so far, and will be looking to overtake Michael van Gerwen and go top in Aberdeen.
Gary Anderson has only played one match in the last couple of weeks after missing out with Covid-19, and he currently sits one point adrift at the bottom of the standings.
The Flying Scotsman will be looking to feed off the home crowd here and he certainly needs a boost as despite winning a league night he's won just four matches in total this season.
One of those matches has been against Clayton though so there is hope, but Clayton has won three of the last four meetings and looks in much better form for this one.
Peter Wright vs Joe Cullen
Joe Cullen lost last week's final in Manchester and finds himself in fifth place and just on the edge of the battle for the top four spots that will eventually make the play-offs in Berlin.
One place and three points above Cullen in fourth is world champion Peter Wright, who has one nightly win to his name but hasn't made a final since week four.
Snakebite has been chipping away when winning just one match per week over a four-week stretch, and he's been a bit quiet of late away from the Premier League.
It's 1-1 between them in this Premier League season but Wright leads 8-2 over the last 10 meetings and with the Scottish crowd behind him he's fancied to start off with a win in Aberdeen.
James Wade vs Michael Smith
Nobody has been in better form of late in the Premier League than James Wade, who finally got a win last week at the fourth time of asking in his fourth final appearance.
The Machine has been just that with three straight final appearances, and his opening opponent here is a desperate Michael Smith who is yet to taste a weekly Premier League victory after two final appearances.
Bully Boy Smith is 10 points off fourth-placed Wright and running out of time, but he did dispatch Wade 6-1 in their only Premier League meeting this season, so will fancy he can do a job on him in Aberdeen.
Wade is looking a different animal in recent weeks though after powering up into third place in the table, and looks to have too much momentum on his side at present.
Gerwyn Price vs Michael van Gerwen
The Gerwyn v Gerwen derby sees Welshman Gerwyn Price tackle Michael van Gerwen in some need after his hand injury has seen him struggle for form of late.
The Iceman has won both Premier League meetings this season and four of the last five overall, but he's 11 points behind table-topper MVG in the standings.
The Dutchman reached the semi-finals of the Interwetten German Darts Grand Prix at the weekend so is in decent touch, and in the Premier League he's been excellent.
Van Gerwen is the only man to win three weekly events and the only one to win over 100 legs in the tournament (107) and has to hold the edge on current form with Price - who has lost three of his last four matches.