Following a dominant first match that saw England break the world record for number of runs in a one-day international, Matthew Mott's side put on another impressive display in Amsterdam on Sunday.
Rain delayed the start of the match by nearly two hours, meaning each side were given 41 overs instead of the usual 50 to set their score.
The hosts again won the toss but this time chose to bat first. They managed a total of 235 for seven, but England were able to reach the target in just 36.1 overs to secure a six-wicket victory.
The Netherlands, looking to bounce back from their drubbing in the first match, endured a slow start, with openers Vikramjit Singh and Max O'Dowd falling for just 10 and seven after 34 deliveries.
Tom Cooper also offered no resistance against England's assault, with the 35-year-old veteran reaching just 17 before being dismissed.
Bas de Leede and captain Scott Edwards helped steady the side somewhat, with the duo making a collective stand of 112 - Edwards himself scoring 78 from 73.
After 41 overs, England stepped up to start a chase of 235, and immediately Jason Roy and Phil Salt got off to a superb start.
Roy struck 13 fours and one six en-route to his 73, while Phil Salt managed 77 from just 54 deliveries.
Captain Eoin Morgan again struggled with the bat, with the 35-year-old falling for a duck. Liam Livingstone, a star from the first ODI, also endured a frustrating afternoon with just four from six.
But the unbeaten duo of Dawid Malan and Moeen Ali ensured England doubled their series lead and extend their winning start under new coach Matthew Mott.
Malan managed 36 from 50, while Ali struck 42 from 40 to give England a six-wicket victory with 29 balls still remaining.
The final match of the three-game series will take place on Wednesday June 22, with England looking to secure a whitewash victory.