The 48-year-old enjoyed tremendous success during his seven-year spell with the Australia women's team, winning successive T20 World Cups as well as the 50-over equivalent.
Mott also enjoyed an impressive run with Glamorgan after helping them to the Yorkshire Bank 40 final in 2013.
The new coach has now been tasked with replicating that success with the England men's team, after edging out Paul Collingwood for the role and signing a four-year deal.
The appointment means that for the first time since 2014, England will have separate head coaches in the red and white-ball roles - with Brendon McCullum taking over responsibility for the Test team.
Mott is expected to make his coaching bow next month when England takes on Holland in three one-day internationals.
The new coach said: "It was always going to take something special to leave the role that I have loved for the past seven years with the Australian Women's team.
"However, I genuinely believe that the time is right to play a role in helping the England men's ODI and T20 group continue to evolve as one of the best teams in the world.
"The idea of the split roles and the chance to work alongside Brendon McCullum in his red-ball role is an opportunity that I am incredibly enthusiastic about."
While McCullum looks to improve England's dreadful Test run of one win from 17, Mott will have high expectations on his shoulders, with the team entering this year's T20 World Cup as one of the hot favourites.
Mott will also have his sights on retaining the 50-over World Cup, with the tournament set to take place in India next year.
He added: "Since the excitement of accepting this role, I, like many people around the world, have been trying to come to terms with the tragic loss of my great mate Andrew Symonds.
"The support of his beautiful family and close friends in the coming days will be vitally important, so I respectfully request some time to process his passing and the immense loss before making any further comment on the role at this stage."