The American kept hold of his WBO junior-lightweight title thanks to a devastating performance which saw Frampton's corner throw in the towel half way through the fight.
Herring was in control from the opening bell and knocked Frampton down in the fifth and sixth rounds.
The Northern Irish man got up on both ocassions however, his corner had seen enough and decided to stop the fight.
Frampton promised that he would retire should he fail to win and the 34-year-old stuck true to his words.
In the post-fight interview, Frampton told Channel 5: "I said I would retire if I lost this fight and that is what I am going to do. I want to dedicate my life to my family now. Boxing has been good to me. I want to go home to my beautiful wife and kids and dedicate my life to them.
"I was just beaten by the better man. Perfect game plan and I just got beat. Zero excuses. I had an amazing camp and came into it to win it. I got beaten by the better man."
Frampton's decision to retire ends an incredible professional journey which started all the way back in 2009.
The boxer ends his career with a record of 28 wins, 16 by knockout and just three defeats.