The 33-year-old Russian produced a ruthless display as he dispatched Liam Taylor in quick time to retain his European welterweight title.
Avanesyan's power was clear for all to see as he forced Taylor onto one knee before stopping the challenger on the ropes.
This was the evening's main event as Chris Eubank Jr's scheduled fight against Anatoli Muratov was cancelled earlier in the day.
The decision was made after the British Boxing Board of Control raised concerns over pre-bout medicals.
Muratov was already a replacement for Sven Elbir who pulled out last week after testing positive for Covid-19.
It is expected that a new fight date for Eubank Jr will be announced in the next few weeks.
Earlier in the night, Germaine Brown improved his perfect record to 10 wins from 10 following his points victory over Jamal Le Doux.
Linus Udofia also maintained his unbeaten status thanks to a knockout victory over Albania's Xhuljo Vrenozi.
In the cruiserweight division, Richard Riakporhe was able to earn a points victory over Poland's Krzysztof Twardowski.
The London-born fighter will now set his sights on the vacant WBC Silver Cruiserweight title which he'll have the chance to win in next month's fight with Olanrewaju Durodola.
Sticking with cruiserweights, Mikael Lawal extended his perfect record to 14-0 with a knockout victory against Benoit Huber.
Ebonie Jones, meanwhile, kicked off her professional career with a points victory over Lithuania's Vaida Masiokaite.