The 28-year-old takes on former world titlist Krzysztof Glowacki this weekend for the WBO cruiserweight title.
Okolie is one of five male fighters from the 2016 Olympic Games with Joe Cordina, Josh Kelly, Anthony Fowler and Joshua Buatsi also signed with Matchroom Boxing.
Okolie alongside Cordina and Buatsi are the only three to remain undefeated from the Olympic quintuple with Fowler tasting defeat to Scott Fitzgerald in 2019 and Kelly more recently relinquishing his unbeaten record to David Avanesyan in February 2020.
Managed by Anthony Joshua, Okolie is hoping to take over the 200-pound division before turning his attention to the heavyweight elite.
When and where is the fight?
The fight is taking place on March 20.
Despite no fans being allowed into the venue, Okolie's attempt at world glory will take place at Wembley Arena in London, England.
Who is the favourite?
Despite having less experience, Okolie is the clear favourite according to Sky Bet with odds of 1/3.
A draw is 22/1 while Glowacki is 9/4.
Where can I watch Okolie vs Glowacki?
UK & Ireland: Sky Sports Main Event
USA & rest of the world: DAZN
What has Okolie said?
"For me, it's how comfortably I can make the weight. I don't enjoy it," Okolie told Sky Sports News.
"It's not hard, it's just I enjoy eating, full stop, so I have to be a little bit cautious. I have to go for long runs.
"I owe it to myself to win this fight and have some unification matches, so I can say I've cemented my legacy on Saturday by being British, Commonwealth, European and world champion, however, for me it's not enough to have a cabinet full of those belts.
"I want WBO and IBF and WBC and WBA, so we'll see how many I can grab while I can still make the weight, and then we'll move up."
What are their records?
"The Sauce" is undefeated from 15 bouts and has won the British, Commonwealth and European titles at cruiserweight.
His biggest win to date is Yves Ngabu, whom he stopped in 2019 to win the EBU strap.
Glowacki, meanwhile, is 31-2 with 19 victories coming inside the distance.
His standout win is over Maxim Vlasov for the WBO title although he lost it in his first defence to Mairis Briedis in the World Boxing Super Series semi-final.