Andrade (30-0 18 KOs) puts his crown on the line for the fifth time and the Rhode Island star will be looking for a statement win as he hunts the unification blockbusters with his fellow belt holders at 160lbs.
The 33-year-old, who picked up the vacant strap in his first fight with Eddie Hearn in Boston in October 2018, will make it five straight fights with European challengers when he steps through the ropes against Quigley.
Quigley (19-1 14 KOs) moved into prime position to land a world title shot in May by beating Golden Boy stablemate Shane Mosley Jr by majority decision in a thriller in Las Vegas. The former amateur star becomes the second Irishman to challenge 'Boo Boo' after Luke Keeler took on the WBO ruler in Miami in January 2020.
"November 19, it's me again," said Andrade. "Jason Quigley, world rated, good amateur pedigree, decent skills, comes to fight, and hats off to him, he's actually willing to step in the ring with me, which you can't say for any of these other so-called top guys. On November 19 though I show him that there are levels to this game.
"Just keep winning, that's all I can do," Andrade continued. "Go in there, handle my business, do my job, look sensational, come out healthy and then it's onto the next.
"If you have a belt at 160 or 168 lbs, let's go. Put the politics aside, have your people call Eddie [Hearn]. Let's get down to business. Charlo, stop running your mouth, making up excuse after excuse. You're a fighter, let's fight bro. GGG, where you at? Unify against Murata and then let's put the three belts on the line next year.
"Canelo you going to run up to 175? Cool, I can meet you there, no problem. First things first though, I need to go out on November 19, defend my championship belt, and put on a spectacular performance, and that's exactly what I plan on doing."
"I've worked my whole career to get into this position of becoming world champion," said Quigley. "Demetrius is a great champion but now it's my time and that world title is coming back to Ireland."
Akhmadaliev vs Rios
Three more world title fights in support of Andrade's clash with Quigley are led by Murodjon Akhmadaliev defending his IBF and WBA world super bantamweight titles against Ronny Rios.
Akhmadaliev (9-0 7 KOs) was at his spiteful best last time out, putting the challenge of Ryosuke Iwasa to bed in the fifth round of his first professional outing in his homeland of Uzbekistan.
'MJ', who became unified champion in just his eighth fight in the paid ranks by ripping the belts from Daniel Roman, puts the belts on the line for the second time in New Hampshire and does so against his WBA mandatory challenger and #1 in the rankings.
Rios (33-3 16 KOs) is in great form heading into his second world title challenge, heading to the east coast on the back of four wins, the latest being the only one to go the distance in February in Indio, California with a wide points win over Oscar Negrete.
"I would like to thank my promoters Eddie Hearn and Andrei Ryabinsky for the opportunity to defend my titles in New Hampshire," said Akhmadaliev. "I'm living and training in Indio, so I know how people love and appreciate boxing here.
"It will be my second mandatory challenger in a row, he's a good fighter and I expect it to be a great fight for everybody to enjoy! As always, I'm working hard with my coaches Antonio and Joel Diaz, and we'll be prepared to defend what belongs to us!"
"Who is the best to beat at my weight class? It's MJ so I am here to challenge myself with this task and I'm confident in my ability and my team to come out victorious," said Rios. "On November 19 you will see a new world champion added to the Golden Boy stable"
Martinez and Arroyo finally meet
The third world title fight is Mexico vs. Puerto Rico and it's the long-awaited showdown between Julio Cesar Martinez and McWilliams Arroyo.
Mexican Martinez (18-1 14 KOs) returned to action in typically entertaining fashion in June, stopping Joel Cordova in Guadalajara to successfully defend his WBC World Flyweight title for the third time.
It will be third time lucky for the Arroyo clash. Covid squashed the first attempt to put them together in Tulsa in May 2020 while a hand injury to Martinez in February ruled him out in fight week when they were due to clash on the undercard of Canelo Alvarez's clash with Avni Yildirim in Miami.
Puerto Rican Arroyo (21-4 16 KOs) was able to taste action that night and picked up the interim title at the home of the Miami Dolphins with a fifth round win over Abraham Rodriguez, and will be desperate to upgrade and rip the full title from Martinez as they finally get to tangle.
"It is great that we are finally able to get this fight," said Martinez. "We have tried twice to do it but that's all in the past and now we're going to go to war on October 16.
"McWilliams is a strong challenger for the belt but I feel fantastic and I am ready to prove that I am the man to beat at flyweight."
"This fight has been asked for and the fans will finally get a great battle on November 19," said Arroyo. "I hope he will come prepared because I am going to be 100 per cent ready and confident that I will be victorious."
Stakes high in lightweight bout
The fourth world title bout on the bill is the second step on the path to crowing an undisputed women's champion at 140lbs as Kali Reis takes on Jessica Camara for the WBA, IBO and vacant WBO straps.
Two-weight champion Reis (18-7-1 5 KOs) added the IBO title to her WBA crown last time out with a majority decision win over Australian Diana Prazak.
The Rhode Island champion and former WBC middleweight ruler will be looking to add another title through victory over Camara (8-2) - the Canadian that bounced back from defeat to Melissa St Vil with a confidence boosting win over Heather Hardy in May - and the stakes couldn't be higher with the winner set to face WBC and IBF champion Chantelle Cameron.
"I am in this tournament (Road to Undisuted) to collect all of the belts and become undisputed champion," said Reis. "I want to thank DAZN, Lou DiBella and Eddie Hearn for this tremendous opportunity," said Kali Reis. "Jessica is a talented fighter, but she will not deter me from achieving my goal. No one will."
"This is going to be a fun fight for the fans and a great fight for women's boxing," said Camara.
"Kali will be a tough opponent, but I will be ready. On November 19, I will become a world champion. Thank you to DAZN, Lou DiBella and Eddie Hearn for putting this historic tournament together to crown an undisputed super lightweight champion."