Vasiliy Lomachenko will make his ring return on June 26 to face Masayoshi Nakatani in the first fight since recovering from shoulder surgery.
The boxing great - who tasted defeat to Teofimo Lopez last year - begins his comeback trail against the Japanese in Las Vegas.
Nakatani has just one defeat from 20 bouts, which came from Lopez who won via unanimous decision in July 2019.
He is, however, capable of producing an upset if his last fight is to go off.
The 32-year-old picked himself up from the canvas twice to knock out Felix Verdejo in the ninth-round and earn a TKO win.
Loma is hoping to secure a rematch with Lopez, who prepares to make the first defence of his WBA, IBF and WBO world titles against game Australian George Kambosos on June 5.
"You learn from those guys. He's [Lomachenko] a two-time Olympic gold medalist. He had 396 wins, one loss in the amateurs," Lopez told Fight Hub TV.
"Three-division world champion (as a pro). This guy is what a lot of people were saying. He was one of the top dudes, and still is! In my division, he is after me.
"On a serious note, that's just part of how it is. (After) Floyd Mayweather, if you have one loss in the sport of boxing, you're pretty much forgotten.
"When it comes to UFC, you can have multiple losses and people still support. Conor McGregor comes back and gets fighting again, they'll still support him, even after him getting pounded on by Dustin (Poirier)."
Lomachenko's comeback bout will be live on ESPN, the same night Gervonta "Tank" Davis locks horns with Mario Barrios on Showtime pay-per-view.
"The Takeover" is 1/12 to win his upcoming bout while his opponent, who previously defeated former world champion Lee Selby is an underdog at 6/1.
For a draw, you get can odds of 22/1 by Paddy Power.
The confident Lopez, who is set for a purse of around $4million, is hoping victory can secure him a showdown with a big name from the 135-pound division to cement his legacy in the sport.
"In the United States, they may not recognize George Kambosos as much. Maybe so. But a lot of people know Teofimo, and if you don't know, you will, God willing," he said.
"The whole thing is just making the fights happen. And obviously if I didn't make this fight with Kambosos, I have to give up the IBF title. And that defeats the purpose of being undisputed.
"I'm not gonna give up my belt, so I have to take this route at the moment. It's more of a pit stop or a detour.
"I'll go out there, do what I have to do, and then we'll come back talking about (Haney, Garcia, and Davis) and these other fighters in my division."