Canelo and Golovkin first went head-to-head in 2017 with the fight ending in a split decision draw.
A year later, the pair went toe-to-toe for a second time, with the Mexican fighter winning a controversial majority decision.
Four years on, the duo will square off in the ring for the final time as their epic trilogy comes to a conclusion.
The two men will battle on September 17 at the T-Mobile Arena in Paradise, Nevada - the same venue as their first two fights.
During Friday's press conference, Canelo was in a fiery mood as he hit out at his opponent, saying: "He talks bad about me. Now he doesn't, but in other sides he always talks s**t.
"Now he doesn't because he has me in front of him. It's not the same to call the lion than to see him coming.
"He always pretends he's a nice guy in front of everyone, but he's an a*****e, that's what he is. I don't pretend to be different, I am the way I am, I don't want to be someone else. He always pretends in front of you to be a good guy."
When asked whether he wants to hurt his opponent, Canelo said: "Yes, because he always talks about me, a lot of s**t about me. I'm more dangerous now than before.
Alvarez suffered the second defeat of his career last May after losing on points to Dmitry Bivol for the WBA light heavyweight title.
Golovkin returned to action last April when he defeated Ryota Murata with a ninth round knockout in Japan.
"I was busy fighting the best, making history, winning titles, moving up and down in weight. Trying to make history. While he was fighting class c or class d opponents," said Canelo when asked why the trilogy bout took four years to arrange.
"It wasn't my intention to fight him but the people want this fight, that's why I'm making it, but I didn't want to, at the end of the day, I feel like this was already over, doing other bigger and more interesting things."
Canelo also promised to end the feud in style, adding: "With a knockout. That's the only way I want to end this rivalry."