Amanda Serrano retained her WBC and WBO featherweight titles after stopping Daniela Bermudez inside the distance with a body shot.
The Puerto Rican earned her 40th professional victory via KO in the ninth round and extended her record to 40-1-1.
Regarded as the hardest punching fighter in women's boxing, Serrano delivered an impressive showing against an opponent who is a former three-division world champion.
All three judges had the bout 80-72 in favour of Serrano at the timing of the knockout.
Despite Serrano - a six-division world champion - being linked to a super-fight with Ireland's Katie Taylor, the 32-year-old is focused on becoming Puerto Rico's first undisputed champion.
"We knew she was tough, she's a Latina, she's from Argentina," Serrano said.
"They are very tough women. We were ready for a 10-round war. It just happened, the body shot."
"I want to become undisputed. I want to be the first undisputed champion from Puerto Rico," she continued.
"IBF, WBA, nothing against any champion, I want those belts. If they want to become the undisputed champion, they need to come through me, too, so we need each other."
Serrano holds the WBC and WBO featherweight titles while Jelena Mrdjenovich (41-10-2, 19 KO) of Canada holds the WBA version.
Undefeated Dane Sarah Mahfoud (10-0, 3 KO) has the IBF title but Serrano would be fancied to beat both of them should either fight come into fruition.
Will Taylor vs Serrano ever happen?
Time is running out.
Two of the biggest names in the game, alongside Claressa Shields, were expected to go toe-to-toe in May 2020 for the lightweight titles.
The contest got postponed due to the Coronavirus pandemic and never got rescheduled due to an insulting offer from Eddie Hearn, according to Serrano's team.
Money is the sticking point.
If the right offer is made then Serrano will accept it but 2021 is out the equation one would imagine.
Taylor is defending her belts against Natasha Jonas next on the undercard of Derek Chisora versus Joseph Parker in May before a big fight later this year.
With Jessica McCaskill defeating Cecilia Braekhus for a second time to confirm her status as welterweight's undisputed champion, Taylor may be eyeing up a piece of history by becoming a third-division titlist.
All will be revealed but firstly, Taylor must overcome Jonas in London before she looks to cement her growing legacy.